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    Nudt6 nudix hydrolase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 207120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nudt6provided by RGD
    Official Full Name
    nudix hydrolase 6provided by RGD
    Primary source
    RGD:621356
    See related
    EnsemblRapid:ENSRNOG00000017420 AllianceGenome:RGD:621356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gfg
    Summary
    Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Predicted to be involved in negative regulation of cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Orthologous to human NUDT6 (nudix hydrolase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 64.4), Liver (RPKM 64.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt6 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (122218031..122234488, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (120289908..120306197, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (124134301..124149824, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene centrin 4 Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene fibroblast growth factor 2 Neighboring gene AFG2 AAA ATPase homolog A Neighboring gene small nucleolar RNA SNORA51 Neighboring gene 60S ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of alternatively spliced FGF-2 antisense RNA transcripts in the central nervous system: regulation of FGF-2 mRNA translation. Li AW, et al. Mol Cell Endocrinol, 2000 Apr 25. PMID 10854699
    2. Characterization and tissue-specific expression of the rat basic fibroblast growth factor antisense mRNA and protein. Knee R, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144169, Free PMC Article
    3. FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling. Uzay B, et al. J Physiol, 2024 Apr. PMID 38468384
    4. The fibroblast growth factor-2 antisense gene inhibits nuclear accumulation of FGF-2 and delays cell cycle progression in C6 glioma cells. Baguma-Nibasheka M, et al. Mol Cell Endocrinol, 2007 Mar 15. PMID 17306451
    5. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Asa SL, et al. Mol Endocrinol, 2001 Apr. PMID 11266510

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling.
      Title: FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling.
    2. The results suggest that the endogenous FGF antisense RNA may play a significant functional role in the regulation of FGF-2 dependent cell proliferation in FGF-2 expressing cells.
      Title: The fibroblast growth factor-2 antisense gene inhibits nuclear accumulation of FGF-2 and delays cell cycle progression in C6 glioma cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH pyrophosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate-linked moiety X motif 6
    Names
    antisense basic fibroblast growth factor
    nudix (nucleoside diphosphate linked moiety X)-type motif 6
    nudix motif 6
    NP_852028.1
    XP_038957610.1
    XP_038957611.1
    XP_063137345.1
    XP_063137346.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181363.3 → NP_852028.1  nucleoside diphosphate-linked moiety X motif 6

      See identical proteins and their annotated locations for NP_852028.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P70563, Q9QZD7
      UniProtKB/TrEMBL
      A6II08, A6II09
      Conserved Domains (2) summary
      cd04670
      Location:139 → 271
      Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
      pfam18290
      Location:43 → 126
      Nudix_hydro; Nudix hydrolase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      122218031..122234488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101682.2 → XP_038957610.1  nucleoside diphosphate-linked moiety X motif 6 isoform X1

      UniProtKB/TrEMBL
      A6II08
      Related
      ENSRNOP00000104370.1, ENSRNOT00000168516.1
      Conserved Domains (2) summary
      cd04670
      Location:139 → 271
      Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
      pfam18290
      Location:43 → 126
      Nudix_hydro; Nudix hydrolase domain

    2. XM_063281276.1 → XP_063137346.1  nucleoside diphosphate-linked moiety X motif 6 isoform X4

      UniProtKB/TrEMBL
      A6II10, A6II11

    3. XM_039101683.2 → XP_038957611.1  nucleoside diphosphate-linked moiety X motif 6 isoform X2

      Conserved Domains (2) summary
      cd04670
      Location:66 → 198
      Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
      pfam18290
      Location:4 → 53
      Nudix_hydro; Nudix hydrolase domain

    4. XM_063281275.1 → XP_063137345.1  nucleoside diphosphate-linked moiety X motif 6 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70563.1 GenPept UniProtKB/Swiss-Prot:P70563

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