Ptges2 prostaglandin E synthase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptges2provided by RGD
Official Full Name: prostaglandin E synthase 2provided by RGD
Primary source: RGD:1310836
See related: EnsemblRapid:ENSRNOG00000014050 AllianceGenome:RGD:1310836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; lyase activity; and prostaglandin-E synthase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of DNA-templated transcription and secretion. Predicted to be located in Golgi membrane; cytosol; and nucleus. Predicted to be active in mitochondrion. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 172.7), Muscle (RPKM 165.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (36088246..36095430)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15690501..15697688)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11424195..11431379)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Curcumin has therapeutic effects on TNBS acid-induced colitis, the mechanisms seem to be related to COX-2 inhibition and PGE(2) improvement.
Title: Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2.
Prostaglandin E synthase(PGES)-1 and -2 are colocalized with COX-2 in cardiac myocytes and fibroblasts.
Title: Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin E synthase 2

NP_001101302.1

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107832.1 → NP_001101302.1 prostaglandin E synthase 2

See identical proteins and their annotated locations for NP_001101302.1

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A6JU62, D4AE56

Related

ENSRNOP00000019184.5, ENSRNOT00000019184.8

Conserved Domains (2) summary

cd03197
Location:223 → 371

GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

cd03040
Location:100 → 176

GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...