Prss57 serine protease 57 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss57provided by RGD
Official Full Name: serine protease 57provided by RGD
Primary source: RGD:1303330
See related: EnsemblRapid:ENSRNOG00000025293 AllianceGenome:RGD:1303330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Df2; NSP4; Prssl1
Summary: Predicted to enable heparin binding activity and serine-type endopeptidase activity. Predicted to be involved in protein maturation and proteolysis. Predicted to be located in azurophil granule lumen. Predicted to be active in extracellular space. Orthologous to human PRSS57 (serine protease 57). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1.9), Uterus (RPKM 0.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10563477..10573617)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9915667..9922996)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12798310..12804668)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in azurophil granule lumen	ISO Inferred from Sequence Orthology more info
located_in azurophil granule lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine protease 57

Names: PRSSL1 homolog; complement factor D-like protein; neutrophil serine protease 4; protease, serine, 57; protease, serine-like 1; serine protease 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003956.2 → NP_001003956.1 serine protease 57 precursor

See identical proteins and their annotated locations for NP_001003956.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K8X3, A6K8X4

Conserved Domains (2) summary

smart00020
Location:33 → 203

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:34 → 214

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10563477..10573617

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079725.2 → XP_038935653.1 serine protease 57 isoform X5

Conserved Domains (1) summary

cd00190
Location:46 → 182

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039079723.2 → XP_038935651.1 serine protease 57 isoform X3

UniProtKB/TrEMBL

A6K8X3

Conserved Domains (1) summary

cd00190
Location:46 → 234

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039079718.2 → XP_038935646.1 serine protease 57 isoform X1

UniProtKB/TrEMBL

A0A8L2UKW0

Conserved Domains (1) summary

cd00190
Location:46 → 270

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063264091.1 → XP_063120161.1 serine protease 57 isoform X1

UniProtKB/TrEMBL

A0A8L2UKW0
XM_063264089.1 → XP_063120159.1 serine protease 57 isoform X1

UniProtKB/TrEMBL

A0A8L2UKW0
XM_039079716.2 → XP_038935644.1 serine protease 57 isoform X1

UniProtKB/TrEMBL

A0A8L2UKW0

Conserved Domains (1) summary

cd00190
Location:46 → 270

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063264092.1 → XP_063120162.1 serine protease 57 isoform X2

UniProtKB/Swiss-Prot

Q6IE59

UniProtKB/TrEMBL

A0A8L2UKW0
XM_006240979.5 → XP_006241041.1 serine protease 57 isoform X2

See identical proteins and their annotated locations for XP_006241041.1

UniProtKB/Swiss-Prot

Q6IE59

UniProtKB/TrEMBL

A0A8L2UKW0

Related

ENSRNOP00000031690.5, ENSRNOT00000038553.5

Conserved Domains (1) summary

cd00190
Location:34 → 258

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039079724.2 → XP_038935652.1 serine protease 57 isoform X4

UniProtKB/TrEMBL

A0A8L2UKW0

Conserved Domains (1) summary

cd00190
Location:1 → 211

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...