Phlda1 pleckstrin homology-like domain, family A, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phlda1provided by RGD
Official Full Name: pleckstrin homology-like domain, family A, member 1provided by RGD
Primary source: RGD:3836
See related: AllianceGenome:RGD:3836
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tdag
Summary: Predicted to enable phosphatidylinositol phosphate binding activity. Involved in forebrain neuron differentiation; positive regulation of apoptotic process; and response to aldosterone. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Biomarker of retinal degeneration. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 72.0), Lung (RPKM 63.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (48853690..48855894)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (46967433..46969637)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (54247460..54249664)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of basic helix-loop-helix family member e40 on cerebral ischemia/reperfusion injury: Inhibition of apoptosis via repressing the transcription of pleckstrin homology-like domain family A, member 1.
Title: Protective effect of basic helix-loop-helix family member e40 on cerebral ischemia/reperfusion injury: Inhibition of apoptosis via repressing the transcription of pleckstrin homology-like domain family A, member 1.
role in oxidative stress and ischemia reperfusion-induced myocardial injury
Title: PHLDA1 is a new therapeutic target of oxidative stress and ischemia reperfusion-induced myocardial injury.
Expression of PHLDA1 was elevated in ischemic cardiomyopathy. Overexpression of PHLDA1 promotes apoptosis of cardiac muscle cell.
Title: Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy.
The expression of Phlda1 mRNA is significantly elevated 3 days after induction of cryptorchidism.
Title: Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in FasL biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within FasL biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in forebrain neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pleckstrin homology-like domain family A member 1

Names: PQ-rich protein; PQR protein; T-cell death associated; proline- and glutamine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.