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    Sdr9c7 short chain dehydrogenase/reductase family 9C, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sdr9c7provided by RGD
    Official Full Name
    short chain dehydrogenase/reductase family 9C, member 7provided by RGD
    Primary source
    RGD:628716
    See related
    EnsemblRapid:ENSRNOG00000086854 AllianceGenome:RGD:628716
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rdhs; Sdro; Rdh20; Sdr-o
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 13. Orthologous to human SDR9C7 (short chain dehydrogenase/reductase family 9C member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 53.9), Lung (RPKM 31.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sdr9c7 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65588726..65607534)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63703788..63720325)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (71152366..71169510)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16, pseudogene 1 Neighboring gene retinol dehydrogenase 9 Neighboring gene retinol dehydrogenase 7 Neighboring gene high mobility group protein B1-like Neighboring gene ubiquinol-cytochrome c reductase binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In search for function of two human orphan SDR enzymes: hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O). Kowalik D, et al. J Steroid Biochem Mol Biol, 2009 Nov. PMID 19703561
    2. Identification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activity. Song MS, et al. J Biol Chem, 2003 Oct 10. PMID 12855677
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    short-chain dehydrogenase/reductase family 9C member 7
    Names
    orphan short chain dehydrogenase/reductase
    orphan short-chain dehydrogenase / reductase
    retinol dehydrogenase 20
    retinol dehydrogenase similar protein
    XP_006241577.1
    XP_006241578.1
    XP_008763654.1
    XP_017450708.1
    XP_038936441.1
    XP_038936442.1
    XP_063120674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65588726..65607534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241515.5 → XP_006241577.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X1

      See identical proteins and their annotated locations for XP_006241577.1

      UniProtKB/TrEMBL
      A6HQX8, F1MAS7
      Conserved Domains (1) summary
      cd09805
      Location:26 → 302
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    2. XM_017595219.3 → XP_017450708.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X1

      UniProtKB/TrEMBL
      A6HQX8, F1MAS7
      Conserved Domains (1) summary
      cd09805
      Location:26 → 302
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    3. XM_008765432.4 → XP_008763654.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X1

      See identical proteins and their annotated locations for XP_008763654.1

      UniProtKB/TrEMBL
      A6HQX8, F1MAS7
      Related
      ENSRNOP00000100491.1, ENSRNOT00000147229.1
      Conserved Domains (1) summary
      cd09805
      Location:26 → 302
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    4. XM_006241516.5 → XP_006241578.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X1

      See identical proteins and their annotated locations for XP_006241578.1

      UniProtKB/TrEMBL
      A6HQX8, F1MAS7
      Conserved Domains (1) summary
      cd09805
      Location:26 → 302
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

    5. XM_063264604.1 → XP_063120674.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X1

      UniProtKB/TrEMBL
      A6HQX8, F1MAS7

    6. XM_039080513.2 → XP_038936441.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:1 → 159
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_039080514.2 → XP_038936442.1  short-chain dehydrogenase/reductase family 9C member 7 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:1 → 159
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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