Oas3 2'-5'-oligoadenylate synthetase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oas3provided by RGD
Official Full Name: 2'-5'-oligoadenylate synthetase 3provided by RGD
Primary source: RGD:1359319
See related: EnsemblRapid:ENSRNOG00000059207 AllianceGenome:RGD:1359319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; regulation of cytokine production; and regulation of innate immune response. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS3 (2'-5'-oligoadenylate synthetase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 21.5), Lung (RPKM 11.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (41439645..41463392)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (35779028..35802781)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (41313081..41368217)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH129983 (e-PCR)
- UniSTS:213271

AI454805 (e-PCR)
- UniSTS:239662

d12rat54 (e-PCR)
- UniSTS:120163

AU027429 (e-PCR)
- UniSTS:113315

AU049134 (e-PCR)
- UniSTS:145582

AU046598 (e-PCR)
- UniSTS:111300

d12arb6 (e-PCR)
- UniSTS:120807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2'-5'-oligoadenylate synthetase activity	IEA Inferred from Electronic Annotation more info
enables 2'-5'-oligoadenylate synthetase activity	ISO Inferred from Sequence Orthology more info
enables 2'-5'-oligoadenylate synthetase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MDA-5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of IP-10 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-X-C motif) ligand 9 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotactic protein-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase 3

Names: (2-5')oligo(A) synthase 3; 2-5A synthase 3

NP_001009493.1

EC 2.7.7.84

XP_038945590.1

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009493.1 → NP_001009493.1 2'-5'-oligoadenylate synthase 3

See identical proteins and their annotated locations for NP_001009493.1

Status: PROVISIONAL

Source sequence(s)

AY250706

UniProtKB/Swiss-Prot

Q5MYT7

UniProtKB/TrEMBL

A0A0G2K4J7

Related

ENSRNOP00000073069.2, ENSRNOT00000090867.3

Conserved Domains (2) summary

cd05400
Location:819 → 998

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:953 → 1134

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

41439645..41463392

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089662.2 → XP_038945590.1 2'-5'-oligoadenylate synthase 3 isoform X1

Conserved Domains (2) summary

cd05400
Location:517 → 647

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:196 → 377

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus