U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nxf1 nuclear RNA export factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59087, updated on 9-Dec-2024

    Summary

    Symbol
    Nxf1provided by RGD
    Full Name
    nuclear RNA export factor 1provided by RGD
    Primary source
    RGD:62014
    See related
    EnsemblRapid:ENSRNOG00000019069 AllianceGenome:RGD:62014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tap; Mex67h
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to act upstream of or within RNA export from nucleus. Predicted to be located in cytoplasm; nuclear inclusion body; and nuclear speck. Predicted to be part of nuclear RNA export factor complex; nuclear pore; and transcription export complex. Predicted to be active in nucleus. Orthologous to human NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 325.7), Lung (RPKM 299.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nxf1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215084563..215097756)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205655442..205668637)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224957535..224970728)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 74 Neighboring gene testis expressed 54 Neighboring gene syntaxin 5 Neighboring gene transmembrane protein 223 Neighboring gene transmembrane protein 179B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables RNA binding  
    enables mRNA binding  
    enables mRNA binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA export from nucleus  
    involved_in biological_process  
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in mRNA export from nucleus  
    involved_in poly(A)+ mRNA export from nucleus  
    involved_in poly(A)+ mRNA export from nucleus  
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus  
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule  
    part_of nuclear RNA export factor complex  
    part_of nuclear RNA export factor complex  
    located_in nuclear inclusion body  
    located_in nuclear inclusion body  
    part_of nuclear pore  
    part_of nuclear pore  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription export complex  
    part_of transcription export complex  
    part_of transcription export complex  

    General protein information

    Preferred Names
    nuclear RNA export factor 1
    Names
    mRNA export factor TAP
    nuclear RNA export factor 1 homolog
    tip-associated protein
    tip-associating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021579.2NP_067590.2  nuclear RNA export factor 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1MA52
      Related
      ENSRNOP00000026033.5, ENSRNOT00000026033.6
      Conserved Domains (5) summary
      smart00804
      Location:555617
      TAP_C; C-terminal domain of vertebrate Tap protein
      cd00780
      Location:381537
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      sd00035
      Location:223265
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:115197
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:264326
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215084563..215097756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Loading
    Loading
    External link. Please review our privacy policy.