Vnn1 vanin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vnn1provided by RGD
Official Full Name: vanin 1provided by RGD
Primary source: RGD:1310075
See related: EnsemblRapid:ENSRNOG00000016219 AllianceGenome:RGD:1310075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tiff66
Summary: Predicted to enable pantetheine hydrolase activity. Predicted to be involved in several processes, including coenzyme A catabolic process; positive regulation of T cell differentiation in thymus; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in plasma membrane and side of membrane. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 395.0), Adrenal (RPKM 319.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (23356324..23366629, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (21537084..21547395, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (22614832..22625134, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury.
Title: In Vivo and In Vitro Evaluation of Urinary Biomarkers in Ischemia/Reperfusion-Induced Kidney Injury.
urinary vanin-1 is a potentially sensitive biomarker for ameliorating renal tubular damage in salt-sensitive hypertension.
Title: Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.
Urinary vanin-1 may serve as a candidate biomarker of renal tubular injury due to hydronephrosis.
Title: Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis.
Pharmacological inhibition of vanin activity attenuates development of transplant vasculopathy. This was accompanied by reduced macrophage infiltration and increased glutathione-synthesizing capacity.
Title: Pharmacological Inhibition of Vanin Activity Attenuates Transplant Vasculopathy in Rat Aortic Allografts.
absence of vanin-1 activity improves insulin sensitivity.
Title: Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells.
Title: Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.
Results suggest that, compared with urinary Kim-1 and neutrophil gelatinase-associated lipocalin, urinary vanin-1 is an earlier and equally sensitive biomarker for drug-induced acute kidney injury.
Title: Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.
Proteomic-based study identifies vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Title: Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131037 (e-PCR)
- UniSTS:214320

Vnn1 (e-PCR), detects polymorphism
- UniSTS:464698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pantetheine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantetheine hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in coenzyme A catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in pantothenate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pantetheinase

NP_001020794.1

EC 3.5.1.92

XP_038958936.1

EC 3.5.1.92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025623.1 → NP_001020794.1 pantetheinase precursor

See identical proteins and their annotated locations for NP_001020794.1

Status: PROVISIONAL

Source sequence(s)

BC098934

UniProtKB/TrEMBL

F7FPD6, Q4KLZ0

Related

ENSRNOP00000021694.4, ENSRNOT00000021694.8

Conserved Domains (1) summary

cd07567
Location:27 → 324

biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

23356324..23366629 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103008.2 → XP_038958936.1 pantetheinase isoform X1

Conserved Domains (2) summary

pfam19018
Location:198 → 344

Vanin_C; Vanin C-terminal domain

cl11424
Location:1 → 184

nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes