Sipa1l3 signal-induced proliferation-associated 1 like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sipa1l3provided by RGD
Official Full Name: signal-induced proliferation-associated 1 like 3provided by RGD
Primary source: RGD:1311432
See related: EnsemblRapid:ENSRNOG00000020703 AllianceGenome:RGD:1311432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including epithelial cell morphogenesis; establishment of epithelial cell polarity; and eye development. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 41.2), Kidney (RPKM 39.5) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93746187..93953606, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84618714..84825956, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (87260832..87467846, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
located_in tricellular tight junction	ISO Inferred from Sequence Orthology more info
located_in tricellular tight junction	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: signal-induced proliferation-associated 1-like protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371098.1 → NP_001358027.1 signal-induced proliferation-associated 1-like protein 3

Status: VALIDATED

Source sequence(s)

BC091303, JAXUCZ010000001

UniProtKB/TrEMBL

A6J9Q9, F1LYG2

Related

ENSRNOP00000041787.5, ENSRNOT00000042207.8

Conserved Domains (4) summary

PHA03247
Location:1065 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1471 → 1721

SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

93746187..93953606 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759131.4 → XP_008757353.1 signal-induced proliferation-associated 1-like protein 3 isoform X2

Conserved Domains (3) summary

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1471 → 1720

SPAR_C; C-terminal domain of SPAR protein
XM_008759130.4 → XP_008757352.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_008757352.1

UniProtKB/TrEMBL

A6J9Q9, F1LYG2

Conserved Domains (4) summary

PHA03247
Location:1065 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1471 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_039104443.2 → XP_038960371.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

UniProtKB/TrEMBL

A6J9Q9, F1LYG2

Conserved Domains (4) summary

PHA03247
Location:1065 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1471 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_017588911.3 → XP_017444400.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

UniProtKB/TrEMBL

A6J9Q9, F1LYG2

Conserved Domains (4) summary

PHA03247
Location:1065 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1471 → 1721

SPAR_C; C-terminal domain of SPAR protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013066.1: Suppressed sequence

Description

NM_001013066.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: SIPA1L3 (GeneID:23094).