Flrt1 fibronectin leucine rich transmembrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flrt1provided by RGD
Official Full Name: fibronectin leucine rich transmembrane protein 1provided by RGD
Primary source: RGD:1565152
See related: EnsemblRapid:ENSRNOG00000022428 AllianceGenome:RGD:1565152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565152
Summary: Predicted to enable fibroblast growth factor receptor binding activity. Predicted to be involved in dendrite development; fibroblast growth factor receptor signaling pathway; and neuron projection extension. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in several cellular components, including focal adhesion; neuronal cell body membrane; and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 66.3), Muscle (RPKM 44.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213704983..213782958, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204275785..204292844, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222340481..222417915, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat transmembrane protein FLRT1

Names: fibronectin leucine rich transmembrane protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109160.1 → NP_001102630.1 leucine-rich repeat transmembrane protein FLRT1

See identical proteins and their annotated locations for NP_001102630.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6HZN4, D4AC39

Conserved Domains (4) summary

PRK15370
Location:58 → 329

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:300 → 386

PCC; polycystin cation channel protein

smart00060
Location:441 → 505

FN3; Fibronectin type 3 domain

sd00033
Location:108 → 128

LRR_RI; leucine-rich repeat [structural motif]