Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Entpd7provided by RGD
Full Name: ectonucleoside triphosphate diphosphohydrolase 7provided by RGD
Primary source: RGD:1310638
See related: EnsemblRapid:ENSRNOG00000016883 AllianceGenome:RGD:1310638
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CTPase activity and GTPase activity. Predicted to be involved in several processes, including T-helper 17 cell differentiation; nucleobase-containing small molecule catabolic process; and ribonucleoside triphosphate metabolic process. Predicted to be located in cytoplasmic vesicle membrane. Orthologous to human ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 62.8), Spleen (RPKM 44.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252508594..252550269)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242559365..242601044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263448633..263490308)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CTPase activity	ISO Inferred from Sequence Orthology more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in CTP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in UDP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleobase-containing small molecule catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 7

Names: bifunctional protein NCOAT-like

NP_001101065.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107595.1 → NP_001101065.1 ectonucleoside triphosphate diphosphohydrolase 7

See identical proteins and their annotated locations for NP_001101065.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHD4, D3ZNB5, D4A7N8

Related

ENSRNOP00000023111.7, ENSRNOT00000023111.8

Conserved Domains (1) summary

cl17037
Location:30 → 264

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily