Fahd1 fumarylacetoacetate hydrolase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fahd1provided by RGD
Official Full Name: fumarylacetoacetate hydrolase domain containing 1provided by RGD
Primary source: RGD:1304560
See related: EnsemblRapid:ENSRNOG00000014727 AllianceGenome:RGD:1304560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304560
Summary: Predicted to enable hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; oxaloacetate decarboxylase activity; and oxaloacetate tautomerase activity. Predicted to be involved in oxaloacetate metabolic process and pyruvate metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human FAHD1 (fumarylacetoacetate hydrolase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14378058..14379497, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13873539..13874978, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14214518..14215957, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylpyruvate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylpyruvate hydrolase activity	ISO Inferred from Sequence Orthology more info
enables acetylpyruvate hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acylpyruvate hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fumarylpyruvate hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fumarylpyruvate hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxaloacetate decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxaloacetate tautomerase activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate tautomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in oxaloacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxaloacetate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oxaloacetate tautomerase FAHD1, mitochondrial

Names: OAA decarboxylase; acylpyruvase FAHD1, mitochondrial; fumarylacetoacetate hydrolase domain-containing protein 1; oxaloacetate decarboxylase; oxaloacetate decarboxylase, mitochondrial

NP_001020162.1

EC 3.7.1.5

EC 4.1.1.112

EC 5.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024991.1 → NP_001020162.1 oxaloacetate tautomerase FAHD1, mitochondrial

See identical proteins and their annotated locations for NP_001020162.1

Status: PROVISIONAL

Source sequence(s)

BC078950

UniProtKB/Swiss-Prot

Q6AYQ8

UniProtKB/TrEMBL

A6HCX6

Related

ENSRNOP00000019767.4, ENSRNOT00000019767.8

Conserved Domains (2) summary

COG0179
Location:16 → 220

MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

pfam01557
Location:18 → 216

FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family