Lat2 linker for activation of T cells family, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lat2provided by RGD
Official Full Name: linker for activation of T cells family, member 2provided by RGD
Primary source: RGD:631397
See related: EnsemblRapid:ENSRNOG00000021856 AllianceGenome:RGD:631397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ntal; Wbscr5
Summary: Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 196.5), Thymus (RPKM 57.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27740647..27754760)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (22104173..22118294)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (25114099..25128381)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that increased asymmetric dimethylarginine (ADMA) efflux mediated by upregulated yLAT2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types.
Title: Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression
Title: Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
The Saturday night forecast called for possible showers or thunderstorms, with winds of 20 to 26 mph. The expected total rainfall Saturday ranges from six-tenths of an inch to an inch, with more possible in thunderstorms, the weather service said.
Title: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
LAT2 and LAT1 form separate membrane microdomains in rat basophilic leukemia cells.
Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
LAT2 colocalizes with Thy-1 (CD90); their colocalization is enhanced following Thy-1 aggregation.
Title: Topography of plasma membrane microdomains and its consequences for mast cell signaling.
Regulates Fc epsilon type I (IgE) receptor-mediated signaling at multiple steps and by different mechanisms in mast cells.
Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: linker for activation of T-cells family member 2

Names: LAT-2 like; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5-like protein; linker for activation of B-cells; non-T cell activation linker

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173840.2 → NP_776212.2 linker for activation of T-cells family member 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q8CGL2

UniProtKB/TrEMBL

A6J0I1

Related

ENSRNOP00000031304.5, ENSRNOT00000034629.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

27740647..27754760

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089532.2 → XP_038945460.1 linker for activation of T-cells family member 2 isoform X3

Conserved Domains (1) summary

pfam15703
Location:51 → 103

LAT2; Linker for activation of T-cells family member 2
XM_039089533.2 → XP_038945461.1 linker for activation of T-cells family member 2 isoform X4

Conserved Domains (1) summary

pfam15703
Location:51 → 103

LAT2; Linker for activation of T-cells family member 2
XM_017598358.3 → XP_017453847.2 linker for activation of T-cells family member 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZWF7, A6J0I2

Related

ENSRNOP00000083189.1, ENSRNOT00000093800.2

Conserved Domains (1) summary

pfam15703
Location:51 → 207

LAT2; Linker for activation of T-cells family member 2
XM_039089531.2 → XP_038945459.1 linker for activation of T-cells family member 2 isoform X1

UniProtKB/Swiss-Prot

Q8CGL2

Conserved Domains (1) summary

pfam15703
Location:51 → 219

LAT2; Linker for activation of T-cells family member 2
XM_039089534.2 → XP_038945462.1 linker for activation of T-cells family member 2 isoform X5

Conserved Domains (1) summary

pfam15703
Location:1 → 127

LAT2; Linker for activation of T-cells family member 2