Camsap3 calmodulin regulated spectrin-associated protein family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camsap3provided by RGD
Official Full Name: calmodulin regulated spectrin-associated protein family, member 3provided by RGD
Primary source: RGD:1597412
See related: EnsemblRapid:ENSRNOG00000000986 AllianceGenome:RGD:1597412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307246
Summary: Predicted to enable actin filament binding activity and microtubule minus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; regulation of microtubule polymerization or depolymerization; and zonula adherens maintenance. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytoskeleton; motile cilium; and zonula adherens. Predicted to colocalize with microtubule minus-end. Orthologous to human CAMSAP3 (calmodulin regulated spectrin associated protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 39.8), Brain (RPKM 24.7) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12p12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (6440959..6464582)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1643062..1666685)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2133935..2157403)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in protein transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of organelle organization	ISO Inferred from Sequence Orthology more info
involved_in zonula adherens maintenance	ISO Inferred from Sequence Orthology more info
involved_in zonula adherens maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule minus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule minus-end	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in zonula adherens	ISO Inferred from Sequence Orthology more info
located_in zonula adherens	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: calmodulin-regulated spectrin-associated protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001144840.1 → NP_001138312.1 calmodulin-regulated spectrin-associated protein 3

See identical proteins and their annotated locations for NP_001138312.1

Status: PROVISIONAL

Source sequence(s)

CH474084

UniProtKB/TrEMBL

A6KQ12, D3ZXQ2

Related

ENSRNOP00000001305.6, ENSRNOT00000001305.9

Conserved Domains (3) summary

pfam08683
Location:1130 → 1248

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:230 → 312

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:604 → 661

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

6440959..6464582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598455.3 → XP_017453944.1 calmodulin-regulated spectrin-associated protein 3 isoform X6
XM_006248776.5 → XP_006248838.1 calmodulin-regulated spectrin-associated protein 3 isoform X1

Related

ENSRNOP00000092580.2, ENSRNOT00000101379.2

Conserved Domains (3) summary

pfam08683
Location:1142 → 1260

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:241 → 323

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:616 → 673

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_063271665.1 → XP_063127735.1 calmodulin-regulated spectrin-associated protein 3 isoform X10
XM_039089766.2 → XP_038945694.1 calmodulin-regulated spectrin-associated protein 3 isoform X3

Conserved Domains (3) summary

pfam11971
Location:230 → 312

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1131 → 1249

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:605 → 662

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_006248779.5 → XP_006248841.1 calmodulin-regulated spectrin-associated protein 3 isoform X4

Related

ENSRNOP00000084006.2, ENSRNOT00000096347.2

Conserved Domains (3) summary

pfam08683
Location:1126 → 1244

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:225 → 307

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:600 → 657

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_063271666.1 → XP_063127736.1 calmodulin-regulated spectrin-associated protein 3 isoform X11
XM_006248777.5 → XP_006248839.1 calmodulin-regulated spectrin-associated protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AHT4

Conserved Domains (3) summary

pfam08683
Location:1141 → 1259

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:241 → 323

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:615 → 672

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_006248781.5 → XP_006248843.1 calmodulin-regulated spectrin-associated protein 3 isoform X7

UniProtKB/TrEMBL

A0A8I6AFS8

Related

ENSRNOP00000087038.1, ENSRNOT00000108516.2

Conserved Domains (3) summary

pfam08683
Location:1115 → 1233

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:214 → 296

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:589 → 646

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_008769001.4 → XP_008767223.1 calmodulin-regulated spectrin-associated protein 3 isoform X5

UniProtKB/TrEMBL

A0A8I6G9R5

Conserved Domains (3) summary

pfam08683
Location:1125 → 1243

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:225 → 307

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:599 → 656

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_006248782.5 → XP_006248844.1 calmodulin-regulated spectrin-associated protein 3 isoform X8

Conserved Domains (3) summary

pfam08683
Location:1114 → 1232

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam11971
Location:214 → 296

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:588 → 645

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_017598456.3 → XP_017453945.1 calmodulin-regulated spectrin-associated protein 3 isoform X9
XM_063271667.1 → XP_063127737.1 calmodulin-regulated spectrin-associated protein 3 isoform X12
XM_063271668.1 → XP_063127738.1 calmodulin-regulated spectrin-associated protein 3 isoform X13

UniProtKB/TrEMBL

A0A0G2K5C0

Related

ENSRNOP00000073369.1, ENSRNOT00000084906.3