Ascc2 activating signal cointegrator 1 complex subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ascc2provided by RGD
Official Full Name: activating signal cointegrator 1 complex subunit 2provided by RGD
Primary source: RGD:1561422
See related: EnsemblRapid:ENSRNOG00000007349 AllianceGenome:RGD:1561422
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561422
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Predicted to be active in cytosolic ribosome. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 138.0), Testes (RPKM 91.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83726975..83771312)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79503449..79547801)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84873507..84913923)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA repair complex	ISO Inferred from Sequence Orthology more info
part_of activating signal cointegrator 1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activating signal cointegrator 1 complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109091.1 → NP_001102561.1 activating signal cointegrator 1 complex subunit 2

See identical proteins and their annotated locations for NP_001102561.1

Status: PROVISIONAL

Source sequence(s)

CH473963

UniProtKB/TrEMBL

A0A8I6ANY1, A6IKH1, D3ZPJ9

Related

ENSRNOP00000090694.1, ENSRNOT00000109658.2

Conserved Domains (1) summary

cd14364
Location:467 → 506

CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

83726975..83771312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092296.2 → XP_038948224.1 activating signal cointegrator 1 complex subunit 2 isoform X2

UniProtKB/TrEMBL

D3ZPJ9

Conserved Domains (1) summary

cd14364
Location:353 → 392

CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
XM_039092295.2 → XP_038948223.1 activating signal cointegrator 1 complex subunit 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A067, D3ZPJ9

Related

ENSRNOP00000083909.1, ENSRNOT00000117747.2

Conserved Domains (1) summary

cd14364
Location:450 → 489

CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins
XM_063273478.1 → XP_063129548.1 activating signal cointegrator 1 complex subunit 2 isoform X3