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    Gpr137b G protein-coupled receptor 137B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289287, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpr137bprovided by RGD
    Official Full Name
    G protein-coupled receptor 137Bprovided by RGD
    Primary source
    RGD:1307342
    See related
    EnsemblRapid:ENSRNOG00000002480 AllianceGenome:RGD:1307342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tm7sf1
    Summary
    Predicted to be involved in several processes, including negative regulation of bone resorption; positive regulation of TORC1 signaling; and positive regulation of protein localization to lysosome. Predicted to be active in lysosomal membrane. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 272.7), Kidney (RPKM 268.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gpr137b in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (92987792..93026003, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (86003635..86041841, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90670852..90709003)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene EDAR associated via death domain Neighboring gene endoplasmic reticulum oxidoreductase 1 beta Neighboring gene nidogen 1 Neighboring gene uncharacterized LOC134482624

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in lysosomal membrane  
    located_in lysosomal membrane  

    General protein information

    Preferred Names
    integral membrane protein GPR137B
    Names
    transmembrane 7 superfamily member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399407.1NP_001386336.1  integral membrane protein GPR137B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6G770, D3ZK26
      Related
      ENSRNOP00000100489.1, ENSRNOT00000171810.1
      Conserved Domains (1) summary
      cd21476
      Location:20339
      7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001399408.1NP_001386337.1  integral membrane protein GPR137B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K234, D3ZK26
      Related
      ENSRNOP00000072087.2, ENSRNOT00000081530.3
      Conserved Domains (1) summary
      cd21476
      Location:20339
      7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      92987792..93026003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095436.2XP_038951364.1  integral membrane protein GPR137B isoform X1

      UniProtKB/TrEMBL
      D3ZK26
      Conserved Domains (2) summary
      cd21464
      Location:3153
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:20295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

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