Ucn3 urocortin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ucn3provided by RGD
Official Full Name: urocortin 3provided by RGD
Primary source: RGD:1562213
See related: EnsemblRapid:ENSRNOG00000017759 AllianceGenome:RGD:1562213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562213
Summary: Predicted to enable corticotropin-releasing hormone receptor binding activity. Involved in several processes, including cellular response to hypoxia; positive regulation of insulin secretion; and response to corticosterone. Located in axon terminus and varicosity. Orthologous to human UCN3 (urocortin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (71219611..71225904)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66309748..66315996)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69959879..69966532)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.
Title: Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats.
Urocortin 3, the newest member of corticotrophin releasing hormone family polypeptides, is an anorexic factor, which has a strong inhibitory effect on animal appetite regulation. (Review)
Title: Progress in understanding the roles of Urocortin3 (UCN3) in the control of appetite from studies using animal models.
Study showed that acute stress rapidly stimulates Urocortin 3 expression in the paraventricular nucleus of the hypothalamus (PVHap) and identified specific stress-sensitive brain areas that project to the PVHap.
Title: Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation.
Ucn3 does not have an overt role in ameliorating histopathological inflammation in colon.
Title: Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Title: Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle.
A novel divalent calcium ion-mobilizing effect of urocortin 3 in vagal pre-ganglionic neurons of the nucleus ambiguus provides a cellular mechanism for this peptide's role in parasympathetic cardiac regulation.
Title: Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Chronic psychological stress disrupted fasted motility in the antrum and colon via central urocortin 3/arginine vasopression pathways.
Title: Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats.
The results showed that in the ad libitum-fed state, both phenotypes had comparable levels of expression of rostral perifornical hypothalamus Ucn3.Food deprivation decreased hypothalamic expression of Ucn3 in lean but not obese rats.
Title: Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats.
Data show that the major urocortin 3 afferent into the ventromedial nucleus of the hypothalamus originates from the paraventricular nucleus of the hypothalamus and the adjacent posterior part of the bed nucleus of stria terminalis.
Title: Identification of urocortin 3 afferent projection to the ventromedial nucleus of the hypothalamus in rat brain.
Type 2 CRF receptors in the VMH mediate some of the central effects of Ucn 3, and the arcuate nucleus melanocortin system may be a downstream target of VMH CRFR2 neurons.
Title: Injection of Urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone receptor 2 binding	IEA Inferred from Electronic Annotation more info
enables corticotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: urocortin-3

Names: urocortin 3 (stresscopin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.