H2ac4 H2A clustered histone 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2ac4provided by RGD
Official Full Name: H2A clustered histone 4provided by RGD
Primary source: RGD:1589461
See related: EnsemblRapid:ENSRNOG00000070010 AllianceGenome:RGD:1589461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hist1h2ak
Summary: Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation and negative regulation of cell population proliferation. Predicted to be part of CENP-A containing nucleosome. Predicted to be active in nucleus. Orthologous to human H2AC4 (H2A clustered histone 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (47495624..47496127, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (42799884..42800387, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (44840990..44841382, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CENP-A containing nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: H2A clustered histone 4

Names: histone cluster 1, H2ak

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109423.2 → NP_001102893.1 H2A clustered histone 4

See identical proteins and their annotated locations for NP_001102893.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q64598

UniProtKB/TrEMBL

A6KN90, D3ZVK7

Related

ENSRNOP00000087700.1, ENSRNOT00000110197.2

Conserved Domains (2) summary

PTZ00017
Location:1 → 130

PTZ00017; histone H2A; Provisional

cd00074
Location:6 → 120

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...