Akr1c12 aldo-keto reductase family 1, member C12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akr1c12provided by RGD
Official Full Name: aldo-keto reductase family 1, member C12provided by RGD
Primary source: RGD:1359406
See related: EnsemblRapid:ENSRNOG00000033010 AllianceGenome:RGD:1359406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BER1; TBER1; Akr1c13; LOCT364773
Summary: Predicted to enable aldose reductase (NADPH) activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity. Predicted to be involved in steroid metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2070.8) See more
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Genomic context

Location:: 17q12.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (70955288..70971412, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (66045376..66061496, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (69695532..69711654, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases.
Title: Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
TBER1 represents a novel type of 17beta-hydroxysteroid dehydrogenase with unique catalytic properties and tissue distribution that is distinct from the type 5 isozyme.
Title: Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1, member C12

Names: 17beta-hydroxysteroid dehydrogenase; aldo-keto reductase family 1, member C13; liver regeneration-related protein LRRG07

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014240.3 → NP_001014262.3 aldo-keto reductase family 1, member C12

See identical proteins and their annotated locations for NP_001014262.3

Status: PROVISIONAL

Source sequence(s)

BC088169

UniProtKB/TrEMBL

A0A8I6AWI6, F1MAE2, Q2MHD9, Q5I0M4

Related

ENSRNOP00000097567.1, ENSRNOT00000117319.2

Conserved Domains (2) summary

COG0656
Location:8 → 305

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]