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    Prelid3a PRELI domain containing 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prelid3aprovided by RGD
    Official Full Name
    PRELI domain containing 3Aprovided by RGD
    Primary source
    RGD:1582858
    See related
    EnsemblRapid:ENSRNOG00000017954 AllianceGenome:RGD:1582858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slmo1
    Summary
    Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Orthologous to human PRELID3A (PRELI domain containing 3A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 34.2), Adrenal (RPKM 17.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prelid3a in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63268824..63301772)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (60998898..61034821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63202601..63220135)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 6 class V Neighboring gene uncharacterized LOC134482956 Neighboring gene AFG3 like matrix AAA peptidase subunit 2 Neighboring gene cytochrome b-c1 complex subunit 7-like Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene spire-type actin nucleation factor 1 Neighboring gene centrosomal protein 76

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. Miliara X, et al. EMBO Rep, 2015 Jul. PMID 26071602, Free PMC Article
    2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Hasson SA, et al. Nature, 2013 Dec 12. PMID 24270810, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PRELI domain containing protein 3A
    Names
    protein slowmo homolog 1
    slowmo homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109570.1 → NP_001103040.1  PRELI domain containing protein 3A

      See identical proteins and their annotated locations for NP_001103040.1

      Status: VALIDATED

      Source sequence(s)
      CH473971
      UniProtKB/TrEMBL
      A6IXV0, D3ZAN9
      Conserved Domains (1) summary
      pfam04707
      Location:15 → 170
      PRELI; PRELI-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63268824..63301772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097131.2 → XP_038953059.1  PRELI domain containing protein 3A isoform X1

      Conserved Domains (2) summary
      pfam04707
      Location:137 → 277
      PRELI; PRELI-like family
      pfam15229
      Location:6 → 101
      POM121; POM121 family

    2. XM_039097132.2 → XP_038953060.1  PRELI domain containing protein 3A isoform X2

      Conserved Domains (2) summary
      pfam04707
      Location:137 → 292
      PRELI; PRELI-like family
      pfam15229
      Location:6 → 101
      POM121; POM121 family

    3. XM_039097133.2 → XP_038953061.1  PRELI domain containing protein 3A isoform X2

      Conserved Domains (2) summary
      pfam04707
      Location:137 → 292
      PRELI; PRELI-like family
      pfam15229
      Location:6 → 101
      POM121; POM121 family

    4. XM_039097134.2 → XP_038953062.1  PRELI domain containing protein 3A isoform X3

      UniProtKB/TrEMBL
      A6IXU9
      Related
      ENSRNOP00000102968.1, ENSRNOT00000143863.1
      Conserved Domains (1) summary
      pfam04707
      Location:15 → 155
      PRELI; PRELI-like family

    5. XM_063277597.1 → XP_063133667.1  PRELI domain containing protein 3A isoform X3

      UniProtKB/TrEMBL
      A6IXU9

    6. XM_063277599.1 → XP_063133669.1  PRELI domain containing protein 3A isoform X4

      UniProtKB/TrEMBL
      A6IXV0, D3ZAN9

    7. XM_063277598.1 → XP_063133668.1  PRELI domain containing protein 3A isoform X4

      UniProtKB/TrEMBL
      A6IXV0, D3ZAN9

    RNA

    1. XR_005496074.2 RNA Sequence

    2. XR_005496075.2 RNA Sequence

    3. XR_005496076.2 RNA Sequence

      Related
      ENSRNOT00000024144.5
    Nucleotide Protein Strain
    Heading Accession and Version

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