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    Gpr21 G protein-coupled receptor 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr21provided by RGD
    Official Full Name
    G protein-coupled receptor 21provided by RGD
    Primary source
    RGD:1586383
    See related
    EnsemblRapid:ENSRNOG00000078766 AllianceGenome:RGD:1586383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within glucose homeostasis; negative regulation of insulin receptor signaling pathway; and regulation of growth. Predicted to be active in plasma membrane. Orthologous to human GPR21 (G protein-coupled receptor 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 29.1), Lung (RPKM 26.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr21 in Genome Data Viewer
    Location:
    3q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41685072..41688791)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21275289..21279008)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21764377..21767300)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134486087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modifications in GPR21 and GPR82 genes expression as a consequence of metabolic syndrome etiology. Romero-Nava R, et al. J Recept Signal Transduct Res, 2021 Feb. PMID 32583711
    2. G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. Osborn O, et al. J Clin Invest, 2012 Jul. PMID 22653059, Free PMC Article
    3. G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response. Gardner J, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22155242
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modifications in GPR21 and GPR82 genes expression as a consequence of metabolic syndrome etiology.
      Title: Modifications in GPR21 and GPR82 genes expression as a consequence of metabolic syndrome etiology.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396821.1 → NP_001383750.1  probable G-protein coupled receptor 21

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JET6, D3ZA59
      Related
      ENSRNOP00000099718.1, ENSRNOT00000145957.1
      Conserved Domains (1) summary
      cd00637
      Location:31 → 308
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41685072..41688791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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