Crb2 crumbs cell polarity complex component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crb2provided by RGD
Official Full Name: crumbs cell polarity complex component 2provided by RGD
Primary source: RGD:1309368
See related: EnsemblRapid:ENSRNOG00000025498 AllianceGenome:RGD:1309368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309368
Summary: Predicted to enable aspartic-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including embryonic morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and maintenance of epithelial cell apical/basal polarity. Predicted to be located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and cell junction. Predicted to be part of subapical complex. Predicted to be active in apical part of cell and plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 16.4), Lung (RPKM 5.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (41946694..41974629)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (21542138..21564876)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (22037812..22061247)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in ingression involved in gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in maintenance of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in mesoderm formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in notochord formation	ISO Inferred from Sequence Orthology more info
involved_in notochord formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in retinal cone cell development	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of subapical complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein crumbs homolog 2

Names: crumbs 2, cell polarity complex component; crumbs family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135761.2 → NP_001129233.1 protein crumbs homolog 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D4A3W2

Related

ENSRNOP00000035420.3, ENSRNOT00000037257.5

Conserved Domains (4) summary

cd00054
Location:321 → 357

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:657 → 774

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:466 → 589

Laminin_G_2; Laminin G domain

cl22861
Location:901 → 1021

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...