H1f8 H1.8 linker histone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H1f8provided by RGD
Official Full Name: H1.8 linker histoneprovided by RGD
Primary source: RGD:1566236
See related: AllianceGenome:RGD:1566236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H1foo; RGD1566236
Summary: Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in chromosome condensation; epigenetic regulation of gene expression; and negative regulation of DNA recombination. Predicted to be located in female germ cell nucleus. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H1-8 (H1.8 linker histone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 2.1), Testes (RPKM 0.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (150665727..150670846)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (148993133..148998254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (147844658..147849779)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info
enables structural constituent of chromatin	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: H1.8 linker histone

Names: H1 histone family, member O, oocyte-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109351.1 → NP_001102821.1 H1.8 linker histone

See identical proteins and their annotated locations for NP_001102821.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6IL05, D3ZEG0

Conserved Domains (2) summary

PTZ00121
Location:127 → 329

PTZ00121; MAEBL; Provisional

cd00073
Location:44 → 135

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...