Hnrnpr heterogeneous nuclear ribonucleoprotein R [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnprprovided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein Rprovided by RGD
Primary source: RGD:631348
See related: EnsemblRapid:ENSRNOG00000011910 AllianceGenome:RGD:631348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hnrpr
Summary: Enables mRNA 3'-UTR binding activity. Involved in circadian rhythm; mRNA destabilization; and negative regulation of catalytic activity. Located in axon terminus; dendrite; and growth cone. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 292.0), Lung (RPKM 237.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153826482..153872272)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148542999..148574888)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154668194..154699967)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that hnRNP-R regulates the c-fos expression in retinal cells, and that the AU-rich element of c-fos mRNAs contributes to this regulation.
Title: hnRNP-R regulates the PMA-induced c-fos expression in retinal cells.
The expression of hnRNP-R1 and hnRNP-R2 is developmentally regulated in rat retina. hnRNP-R may play roles in retinal development and light-elicited cellular activities.
Title: The expression pattern of heterogeneous nuclear ribonucleoprotein R in rat retina.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF390061 (e-PCR)
- UniSTS:249375

D5Rat57 (e-PCR)
- UniSTS:118925

UniSTS:479130 (e-PCR)
- UniSTS:479130

Hnrpr (e-PCR), detects polymorphism
- UniSTS:479130

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175603.3 → NP_783193.2 heterogeneous nuclear ribonucleoprotein R

See identical proteins and their annotated locations for NP_783193.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

F1LUZ6, Q566E4, Q811S1

Conserved Domains (2) summary

TIGR01648
Location:106 → 627

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

cd21067
Location:27 → 110

NURR_hnRNPR; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein R (hnRNPR) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

153826482..153872272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287850.1 → XP_063143920.1 heterogeneous nuclear ribonucleoprotein R isoform X1

UniProtKB/TrEMBL

Q811S1
XM_063287861.1 → XP_063143931.1 heterogeneous nuclear ribonucleoprotein R isoform X6

UniProtKB/TrEMBL

Q811S1
XM_063287858.1 → XP_063143928.1 heterogeneous nuclear ribonucleoprotein R isoform X4

UniProtKB/TrEMBL

Q811S1
XM_063287857.1 → XP_063143927.1 heterogeneous nuclear ribonucleoprotein R isoform X3

UniProtKB/TrEMBL

Q811S1
XM_063287863.1 → XP_063143933.1 heterogeneous nuclear ribonucleoprotein R isoform X8
XM_063287859.1 → XP_063143929.1 heterogeneous nuclear ribonucleoprotein R isoform X5

UniProtKB/TrEMBL

Q811S1
XM_063287854.1 → XP_063143924.1 heterogeneous nuclear ribonucleoprotein R isoform X2

UniProtKB/TrEMBL

F1LUZ6, Q566E4, Q811S1
XM_039110146.2 → XP_038966074.1 heterogeneous nuclear ribonucleoprotein R isoform X7

UniProtKB/TrEMBL

Q811S1

Conserved Domains (1) summary

TIGR01648
Location:5 → 526

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
XM_063287862.1 → XP_063143932.1 heterogeneous nuclear ribonucleoprotein R isoform X1

UniProtKB/TrEMBL

Q811S1
XM_063287851.1 → XP_063143921.1 heterogeneous nuclear ribonucleoprotein R isoform X1

UniProtKB/TrEMBL

Q811S1
XM_063287855.1 → XP_063143925.1 heterogeneous nuclear ribonucleoprotein R isoform X2

UniProtKB/TrEMBL

F1LUZ6, Q566E4, Q811S1
XM_063287856.1 → XP_063143926.1 heterogeneous nuclear ribonucleoprotein R isoform X2

UniProtKB/TrEMBL

F1LUZ6, Q566E4, Q811S1

Related

ENSRNOP00000015971.6, ENSRNOT00000015971.9
XM_063287852.1 → XP_063143922.1 heterogeneous nuclear ribonucleoprotein R isoform X1

UniProtKB/TrEMBL

Q811S1
XM_063287860.1 → XP_063143930.1 heterogeneous nuclear ribonucleoprotein R isoform X5

UniProtKB/TrEMBL

Q811S1
XM_063287853.1 → XP_063143923.1 heterogeneous nuclear ribonucleoprotein R isoform X1

UniProtKB/TrEMBL

Q811S1