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    Crispld1 cysteine-rich secretory protein LCCL domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crispld1provided by RGD
    Official Full Name
    cysteine-rich secretory protein LCCL domain containing 1provided by RGD
    Primary source
    RGD:1564813
    See related
    EnsemblRapid:ENSRNOG00000017773 AllianceGenome:RGD:1564813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564813
    Summary
    Predicted to be involved in face morphogenesis. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in extracellular space. Orthologous to human CRISPLD1 (cysteine rich secretory protein LCCL domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 16.1), Brain (RPKM 10.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crispld1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (6050970..6098265, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (1267347..1314926, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (663750..711033, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 6A (zeta 1), pseudogene 3 Neighboring gene acyl-CoA dehydrogenase, very long chain, pseudogene 1 Neighboring gene peptidase inhibitor 15 Neighboring gene acyl-CoA binding domain containing 5 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel application for Cocoacrisp protein as a biomarker for experimental pulmonary fibrosis. Balharry D, et al. Biomarkers, 2009 Sep. PMID 19552621
    2. Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. Chiquet BT, et al. Birth Defects Res A Clin Mol Teratol, 2011 Jan. PMID 21254358, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crispld1 signal was primarily detected on the alveolar surface in experimental pulmonary fibrosis
      Title: A novel application for Cocoacrisp protein as a biomarker for experimental pulmonary fibrosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC189557

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich secretory protein LCCL domain-containing 1
    Names
    cocoacrisp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134963.1 → NP_001128435.1  cysteine-rich secretory protein LCCL domain-containing 1

      See identical proteins and their annotated locations for NP_001128435.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      B5DFM5, F7EU15
      Related
      ENSRNOP00000024199.5, ENSRNOT00000024199.7
      Conserved Domains (3) summary
      smart00603
      Location:291 → 375
      LCCL; LCCL domain
      cd05380
      Location:63 → 207
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
      pfam03815
      Location:394 → 492
      LCCL; LCCL domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      6050970..6098265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110140.2 → XP_038966068.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X2

      Related
      ENSRNOP00000108783.1, ENSRNOT00000134665.1
      Conserved Domains (3) summary
      smart00603
      Location:291 → 375
      LCCL; LCCL domain
      cd18813
      Location:62 → 207
      CAP_CRISPLD1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1
      pfam03815
      Location:394 → 486
      LCCL; LCCL domain

    2. XM_008763477.4 → XP_008761699.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X1

      See identical proteins and their annotated locations for XP_008761699.1

      UniProtKB/TrEMBL
      B5DFM5, F7EU15
      Conserved Domains (3) summary
      smart00603
      Location:291 → 375
      LCCL; LCCL domain
      cd05380
      Location:63 → 207
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
      pfam03815
      Location:394 → 492
      LCCL; LCCL domain

    3. XM_063287849.1 → XP_063143919.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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