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    Dnaaf11 dynein axonemal assembly factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299920, updated on 9-Dec-2024

    Summary

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    Symbol
    Dnaaf11provided by RGD
    Full Name
    dynein axonemal assembly factor 11provided by RGD
    Primary source
    RGD:1559937
    See related
    EnsemblRapid:ENSRNOG00000005233 AllianceGenome:RGD:1559937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrtp; Lrrc6; Tslrp
    Summary
    Predicted to be involved in cilium assembly; male gonad development; and protein localization to motile cilium. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and protein localization to cilium. Predicted to be located in cilium. Predicted to be active in apical cytoplasm and cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 19. Orthologous to human DNAAF11 (dynein axonemal assembly factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 198.8), Lung (RPKM 31.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnaaf11 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100033843..100134979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98141525..98245906, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107130402..107231507, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 3 Neighboring gene uncharacterized LOC134479740 Neighboring gene transfer RNA lysine (anticodon CUU) 10 Neighboring gene protein NYNRIN-like Neighboring gene Rab geranylgeranyltransferase subunit alpha, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia. Kott E, et al. Am J Hum Genet, 2012 Nov 2. PMID 23122589, Free PMC Article
    2. Identification of a novel testis-specific leucine-rich protein in humans and mice. Xue JC, et al. Biol Reprod, 2000 May. PMID 10775177
    3. Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Inaba Y, et al. Genes Cells, 2016 Jul. PMID 27353389
    4. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Mali GR, et al. Elife, 2018 Jun 19. PMID 29916806, Free PMC Article
    5. Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Mahuzier A, et al. Nat Commun, 2018 Jun 11. PMID 29891944, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and characterization of the mouse and human Lrrc6 (LRTP) orthologs.
      Title: Identification of a novel testis-specific leucine-rich protein in humans and mice.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC114437

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reproductive system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal assembly factor 11
    Names
    leucine rich repeat containing 6 (testis)
    leucine-rich testis-specific protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025659.2 → NP_001020830.2  dynein axonemal assembly factor 11

      See identical proteins and their annotated locations for NP_001020830.2

      Status: VALIDATED

      Source sequence(s)
      BC097394
      UniProtKB/TrEMBL
      A0A0G2JUV1, A0A8I6APC6, A6HRR2
      Related
      ENSRNOP00000069241.2, ENSRNOT00000086263.3
      Conserved Domains (4) summary
      cd00116
      Location:20 → 127
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:23 → 45
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:46 → 86
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:46 → 98
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      100033843..100134979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078778.2 → XP_038934706.1  dynein axonemal assembly factor 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I6APC6
      Related
      ENSRNOP00000093652.2, ENSRNOT00000093671.3
      Conserved Domains (2) summary
      sd00031
      Location:37 → 59
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 179
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039078777.2 → XP_038934705.1  dynein axonemal assembly factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APC6
      Related
      ENSRNOP00000110103.1, ENSRNOT00000151770.1
      Conserved Domains (2) summary
      sd00031
      Location:37 → 59
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 179
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_063263251.1 → XP_063119321.1  dynein axonemal assembly factor 11 isoform X8

    4. XM_039078782.2 → XP_038934710.1  dynein axonemal assembly factor 11 isoform X7

    5. XM_039078780.2 → XP_038934708.1  dynein axonemal assembly factor 11 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AHZ3
      Conserved Domains (2) summary
      sd00031
      Location:37 → 59
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 179
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    6. XM_039078779.2 → XP_038934707.1  dynein axonemal assembly factor 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHZ3
      Related
      ENSRNOP00000072085.3, ENSRNOT00000084875.3
      Conserved Domains (2) summary
      sd00031
      Location:37 → 59
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 179
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    7. XM_063263250.1 → XP_063119320.1  dynein axonemal assembly factor 11 isoform X6

    8. XM_039078781.2 → XP_038934709.1  dynein axonemal assembly factor 11 isoform X5

      Conserved Domains (2) summary
      sd00031
      Location:37 → 59
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:37 → 179
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. XR_005486579.1 RNA Sequence

    2. XR_005486580.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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