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    Atf7 activating transcription factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atf7provided by RGD
    Official Full Name
    activating transcription factor 7provided by RGD
    Primary source
    RGD:1304940
    See related
    EnsemblRapid:ENSRNOG00000015269 AllianceGenome:RGD:1304940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Predicted to be involved in several processes, including hepatocyte apoptotic process; p38MAPK cascade; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human ATF7 (activating transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 47.6), Spleen (RPKM 46.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atf7 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135537351..135649188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133660491..133750902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144131382..144223463, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Tarbp2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene uncharacterized LOC120093744 Neighboring gene ATP synthase membrane subunit c locus 2 Neighboring gene calcium binding and coiled coil domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer. Guo HQ, et al. J Cancer Res Ther, 2015 Apr-Jun. PMID 26148593
    2. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. Pescini R, et al. J Biol Chem, 1994 Jan 14. PMID 8288576
    3. Role of the ATFa/JNK2 complex in Jun activation. De Graeve F, et al. Oncogene, 1999 Jun 10. PMID 10376527
    4. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Hamard PJ, et al. Nucleic Acids Res, 2007. PMID 17264123, Free PMC Article
    5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclic AMP-dependent transcription factor ATF-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108115.1 → NP_001101585.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

      See identical proteins and their annotated locations for NP_001101585.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474035
      UniProtKB/TrEMBL
      A6KCX2, G3V7X9
      Related
      ENSRNOP00000085221.2, ENSRNOT00000106850.2
      Conserved Domains (3) summary
      cd12192
      Location:47 → 84
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336 → 396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00017
      Location:9 → 31
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001434684.1 → NP_001421613.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      B0BMY0, G3V7X9

    3. NM_001434685.1 → NP_001421614.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      B0BMY0, G3V7X9

    4. NM_001434686.1 → NP_001421615.1  cyclic AMP-dependent transcription factor ATF-7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      B0BMY0, G3V7X9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135537351..135649188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263681.1 → XP_063119751.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

    2. XM_006242396.5 → XP_006242458.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

      Conserved Domains (3) summary
      cd12192
      Location:47 → 84
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:334 → 394
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00017
      Location:9 → 31
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_008765747.4 → XP_008763969.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

      Conserved Domains (3) summary
      cd12192
      Location:47 → 84
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:334 → 394
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00017
      Location:9 → 31
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_063263683.1 → XP_063119753.1  cyclic AMP-dependent transcription factor ATF-7 isoform X2

      UniProtKB/TrEMBL
      G3V7X9
    Nucleotide Protein Strain
    Heading Accession and Version

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