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    Tmed1 transmembrane p24 trafficking protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmed1provided by RGD
    Official Full Name
    transmembrane p24 trafficking protein 1provided by RGD
    Primary source
    RGD:1311679
    See related
    EnsemblRapid:ENSRNOG00000008037 AllianceGenome:RGD:1311679
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Il1rl1l
    Summary
    Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; and plasma membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 87.5), Heart (RPKM 80.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmed1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28336072..28342853, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20059937..20063567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22540422..22544369, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146 Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene coactivator-associated arginine methyltransferase 1 Neighboring gene Yip1 domain family, member 2 Neighboring gene translocase of inner mitochondrial membrane 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. Jenne N, et al. J Biol Chem, 2002 Nov 29. PMID 12237308
    2. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. Dominguez M, et al. J Cell Biol, 1998 Feb 23. PMID 9472029, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108769

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane emp24 domain-containing protein 1
    Names
    interleukin-1 receptor-like 1 ligand
    p24 family protein gamma-1
    p24gamma1
    transmembrane emp24 domain containing 1
    transmembrane emp24 protein transport domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013432.1 → NP_001013450.1  transmembrane emp24 domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001013450.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091167
      UniProtKB/Swiss-Prot
      Q5BK85
      UniProtKB/TrEMBL
      A6JNS6
      Related
      ENSRNOP00000057728.2, ENSRNOT00000061009.6
      Conserved Domains (1) summary
      pfam01105
      Location:33 → 219
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28336072..28342853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765940.4 → XP_008764162.1  transmembrane emp24 domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1Y9
      Conserved Domains (1) summary
      pfam01105
      Location:33 → 233
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    2. XM_006242644.4 → XP_006242706.1  transmembrane emp24 domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000084813.2, ENSRNOT00000100773.2
      Conserved Domains (1) summary
      pfam01105
      Location:33 → 254
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK85.1 GenPept UniProtKB/Swiss-Prot:Q5BK85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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