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    Peak1 pseudopodium-enriched atypical kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Peak1provided by RGD
    Official Full Name
    pseudopodium-enriched atypical kinase 1provided by RGD
    Primary source
    RGD:1312026
    See related
    EnsemblRapid:ENSRNOG00000042519 AllianceGenome:RGD:1312026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1312026
    Summary
    Predicted to enable identical protein binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including focal adhesion assembly; regulation of focal adhesion assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in actin cytoskeleton and focal adhesion. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 118.5), Heart (RPKM 83.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Peak1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (65501068..65715768, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (56605040..56819748, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (60861742..61080128, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 3 Neighboring gene ribosomal protein L17, pseudogene 2 Neighboring gene iron-sulfur cluster assembly 2, pseudogene 2 Neighboring gene high mobility group 20A Neighboring gene uncharacterized LOC120094170 Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene uncharacterized LOC134480186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization. Ha BH, et al. J Biol Chem, 2018 Feb 2. PMID 29212708, Free PMC Article
    2. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Murphy JM, et al. Biochem J, 2014 Jan 15. PMID 24107129, Free PMC Article
    3. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. Bristow JM, et al. J Biol Chem, 2013 Jan 4. PMID 23105102, Free PMC Article
    4. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Wang Y, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534451, Free PMC Article
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase PEAK1
    NP_001101619.1
    XP_006243177.1
    XP_006243178.1
    XP_017451132.1
    XP_038937390.1
    XP_038937392.1
    XP_038937393.1
    XP_038937394.1
    XP_038937395.1
    XP_063121541.1
    XP_063121542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108149.1 → NP_001101619.1  inactive tyrosine-protein kinase PEAK1

      See identical proteins and their annotated locations for NP_001101619.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Related
      ENSRNOP00000061695.1, ENSRNOT00000068658.3
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      65501068..65715768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243115.5 → XP_006243177.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_006243177.1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017595643.3 → XP_017451132.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006243116.5 → XP_006243178.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_006243178.1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039081465.2 → XP_038937393.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039081466.2 → XP_038937394.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    6. XM_039081462.2 → XP_038937390.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    7. XM_039081467.2 → XP_038937395.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    8. XM_039081464.2 → XP_038937392.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
      Conserved Domains (2) summary
      pfam05109
      Location:474 → 851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1490 → 1655
      PKc_like; Protein Kinases, catalytic domain

    9. XM_063265472.1 → XP_063121542.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563

    10. XM_063265471.1 → XP_063121541.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/TrEMBL
      A6J4Q8, D4A563
    Nucleotide Protein Strain
    Heading Accession and Version

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