Pccb propionyl-CoA carboxylase subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pccbprovided by RGD
Official Full Name: propionyl-CoA carboxylase subunit betaprovided by RGD
Primary source: RGD:3265
See related: EnsemblRapid:ENSRNOG00000015869 AllianceGenome:RGD:3265
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable propionyl-CoA carboxylase activity. Predicted to be involved in amino acid catabolic process and fatty acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of catalytic complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCB (propionyl-CoA carboxylase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 903.5), Adrenal (RPKM 548.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (110470197..110520222, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (101591218..101641213, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (109368887..109418871, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134649 (e-PCR)
- UniSTS:217928

RH131981 (e-PCR)
- UniSTS:215264

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables propionyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables propionyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables propionyl-CoA carboxylase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic complex	IEA Inferred from Electronic Annotation more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: propionyl-CoA carboxylase beta chain, mitochondrial

Names: PCCase subunit beta; propanoyl-CoA:carbon dioxide ligase subunit beta; propionyl CoA carboxylase, beta polypeptide; propionyl coenzyme A carboxylase, beta polypeptide; propionyl-CoA carboxylase beta subunit

NP_058726.2

EC 6.4.1.3

XP_063120991.1

EC 6.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017030.2 → NP_058726.2 propionyl-CoA carboxylase beta chain, mitochondrial precursor

See identical proteins and their annotated locations for NP_058726.2

Status: PROVISIONAL

Source sequence(s)

BC078855

UniProtKB/Swiss-Prot

P07633

UniProtKB/TrEMBL

A6I2G1, F7FPI9, Q68FZ8

Related

ENSRNOP00000021657.3, ENSRNOT00000021657.5

Conserved Domains (2) summary

COG4799
Location:39 → 541

MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]

cl23717
Location:66 → 270

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...