Ache acetylcholinesterase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Acheprovided by RGD
Full Name: acetylcholinesteraseprovided by RGD
Primary source: RGD:69313
See related: EnsemblRapid:ENSRNOG00000050841 AllianceGenome:RGD:69313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables acetylcholine binding activity; acetylcholinesterase activity; and choline binding activity. Involved in several processes, including acetylcholine catabolic process; nervous system development; and positive regulation of neurogenesis. Located in several cellular components, including endoplasmic reticulum lumen; membrane raft; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; drug dependence (multiple); epilepsy; myasthenia gravis; and subacute delirium. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 131.4), Brain (RPKM 122.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (25042882..25050608, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19406133..19413713, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22472358..22477052, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sepsis decreased AChE activity by reducing its expression at the neuromuscular junction.
Title: Sepsis decreases the activity of acetylcholinesterase by reducing its expression at the neuromuscular junction.
Paraquat-induced death of hippocampal neurons was partially mediated by AChE variants inducing and cholinergic and gultamatergic transmission disruption.
Title: Primary hippocampal neuronal cell death induction after acute and repeated paraquat exposures mediated by AChE variants alteration and cholinergic and glutamatergic transmission disruption.
Quercetin improves memory and anxiogenic-like behavior in diabetic rats by preventing the increase in Ache activity seen in streptozocin induced diabetes.
Title: Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities.
the induction of PRiMA-linked AChE in osteoblast should be independent to classical estrogen signaling pathway.
Title: Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts.
This study showed that changes in AChE may, at least in part, to lead to memory impairment caused by galactose. Taken together, our results can help understand the etiopathology of classical galactosemia.
Title: Intracerebroventricular D-galactose administration impairs memory and alters activity and expression of acetylcholinesterase in the rat.
Acetylcholinesterase activity was increased in rats subjected to mild hyperhomocysteinemia
Title: Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues.
Hindlimb unloading (simulation of hypogravity) leads to an increase in functional activity of acetylcholinesterase on the background of reduced postsynaptic membrane area occupied by acetylcholine receptors.
Title: [Influence of modeling of gravitational unloading on the postsynaptic acetylcholine receptor organization and acetylcholinesterase activity in neuromuscular synapses of rat fast and slow muscles].
Under all studied experimental conditions, offspring brain acetylcholinesterase (AChE) activity was found to be significantly decreased due to maternal hypothyroidism
Title: Effects of experimentally-induced maternal hypothyroidism on crucial offspring rat brain enzyme activities.
This study demonistrated that brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure.
Title: Reversibility of changes in brain cholinergic receptors and acetylcholinesterase activity in rats following early life arsenic exposure.
AChE has an important role in modulation of early immune responses against Toxoplasma gondii infection.
Title: Influence of Toxoplasma gondii acute infection on cholinesterase activities of Wistar rats.

Submit: New GeneRIF Correction See all GeneRIFs (56)

General gene information

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Markers

D12Wox27 (e-PCR)
- UniSTS:518978

UniSTS:463940 (e-PCR)
- UniSTS:463940

Ache (e-PCR), detects polymorphism
- UniSTS:463940

Ache (e-PCR), detects polymorphism
- UniSTS:527233

Ache (e-PCR), detects polymorphism
- UniSTS:141003

RH130210 (e-PCR)
- UniSTS:213497

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine binding	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine binding	IEA Inferred from Electronic Annotation more info
enables acetylcholine binding	ISO Inferred from Sequence Orthology more info
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholinesterase activity	ISO Inferred from Sequence Orthology more info
enables choline binding	IDA Inferred from Direct Assay more info	PubMed
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	ISO Inferred from Sequence Orthology more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables serine hydrolase activity	IEA Inferred from Electronic Annotation more info
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acetylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetylcholine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in choline metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in choline metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast development	IEA Inferred from Electronic Annotation more info
involved_in osteoblast development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetylcholinesterase

Names: glycolipid-anchored form of acetylcholinesterase

NP_742006.2

EC 3.1.1.7

XP_038945765.1

EC 3.1.1.7

XP_038945766.1

EC 3.1.1.7

XP_038945769.1

EC 3.1.1.7

XP_038945770.1

EC 3.1.1.7

XP_063127785.1

EC 3.1.1.7

XP_063127786.1

EC 3.1.1.7

XP_063127787.1

EC 3.1.1.7

XP_063127788.1

EC 3.1.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172009.3 → NP_742006.2 acetylcholinesterase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P37136

UniProtKB/TrEMBL

A0A0G2K6V0, A0A9K3Y822, Q505J2

Related

ENSRNOP00000073951.2, ENSRNOT00000089392.3

Conserved Domains (2) summary

pfam00135
Location:37 → 563

COesterase; Carboxylesterase family

pfam08674
Location:578 → 611

AChE_tetra; Acetylcholinesterase tetramerisation domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

25042882..25050608 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089838.2 → XP_038945766.1 acetylcholinesterase isoform X1

UniProtKB/TrEMBL

A0A7G5X9Q5, M0R4A5

Conserved Domains (1) summary

pfam00135
Location:37 → 563

COesterase; Carboxylesterase family
XM_063271715.1 → XP_063127785.1 acetylcholinesterase isoform X2

UniProtKB/Swiss-Prot

P37136

UniProtKB/TrEMBL

A0A0G2K6V0, A0A9K3Y822, Q505J2
XM_063271716.1 → XP_063127786.1 acetylcholinesterase isoform X5
XM_063271718.1 → XP_063127788.1 acetylcholinesterase isoform X7
XM_039089837.2 → XP_038945765.1 acetylcholinesterase isoform X1

UniProtKB/TrEMBL

A0A7G5X9Q5, M0R4A5

Conserved Domains (1) summary

pfam00135
Location:37 → 563

COesterase; Carboxylesterase family
XM_039089842.2 → XP_038945770.1 acetylcholinesterase isoform X4

Conserved Domains (1) summary

cl21494
Location:69 → 287

Abhydrolase; alpha/beta hydrolases
XM_063271717.1 → XP_063127787.1 acetylcholinesterase isoform X6
XM_039089841.2 → XP_038945769.1 acetylcholinesterase isoform X3

Conserved Domains (1) summary

pfam00135
Location:37 → 357

COesterase; Carboxylesterase family