Dlg4 discs large MAGUK scaffold protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlg4provided by RGD
Official Full Name: discs large MAGUK scaffold protein 4provided by RGD
Primary source: RGD:68424
See related: EnsemblRapid:ENSRNOG00000018526 AllianceGenome:RGD:68424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dlgh4; PSD95; Sap90
Summary: Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 195.0), Adrenal (RPKM 29.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55239397..55267780)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54740700..54769097)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56625845..56655543)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats.
Title: Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats.
Oligomeric Abeta25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Title: Oligomeric Aβ25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)-Mas on cerebral ischaemia injury.
Title: Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)-Mas on cerebral ischaemia injury.
Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats.
Title: Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats.
Inhibition of the NR2B-PSD95 Interaction Exerts Neuroprotective Effects on Retinal Ischemia-Reperfusion Injury.
Title: Inhibition of the NR2B-PSD95 Interaction Exerts Neuroprotective Effects on Retinal Ischemia-Reperfusion Injury.
Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats.
Title: Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats.
PSD-95 protects synapses from beta-amyloid.
Title: PSD-95 protects synapses from β-amyloid.
Disrupting nNOS-PSD95 Interaction Improves Neurological and Cognitive Recoveries after Traumatic Brain Injury.
Title: Disrupting nNOS-PSD95 Interaction Improves Neurological and Cognitive Recoveries after Traumatic Brain Injury.
Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.
Title: Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.
Title: NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables P2Y1 nucleotide receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables acetylcholine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-1 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-2 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuroligin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NMDA selective glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to potassium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal ion channel clustering	TAS Traceable Author Statement more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of grooming behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of grooming behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic vesicle maturation	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vocalization behavior	IEA Inferred from Electronic Annotation more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cerebellar mossy fiber	IEA Inferred from Electronic Annotation more info
located_in cerebellar mossy fiber	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic branch	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IEA Inferred from Electronic Annotation more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	IEA Inferred from Electronic Annotation more info
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disks large homolog 4

Names: PSD-95; SAP-90; discs, large homolog 4; postsynaptic density protein 95; synapse-associated protein 90; synapse-associated protein SAP90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019621.2 → NP_062567.1 disks large homolog 4

See identical proteins and their annotated locations for NP_062567.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P31016, P97631

UniProtKB/TrEMBL

A0A0G2K7F5

Related

ENSRNOP00000079351.2, ENSRNOT00000095923.2

Conserved Domains (7) summary

cd12030
Location:430 → 495

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00072
Location:544 → 710

GuKc; Guanylate kinase homologues

smart00228
Location:310 → 394

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:65 → 149

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:533 → 711

Guanylate_kin; Guanylate kinase

pfam10600
Location:245 → 312

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 64

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55239397..55267780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246687.5 → XP_006246749.1 disks large homolog 4 isoform X3

UniProtKB/TrEMBL

A0A0G2K7F5

Conserved Domains (6) summary

cd12030
Location:427 → 492

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:307 → 391

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:62 → 146

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:530 → 708

Guanylate_kin; Guanylate kinase

pfam10600
Location:242 → 309

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 61

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_039085767.2 → XP_038941695.1 disks large homolog 4 isoform X2

UniProtKB/TrEMBL

A0A0G2K7F5

Related

ENSRNOP00000080177.2, ENSRNOT00000096075.2

Conserved Domains (6) summary

cd12030
Location:422 → 487

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:302 → 386

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:57 → 141

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:525 → 703

Guanylate_kin; Guanylate kinase

pfam10600
Location:237 → 304

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:6 → 56

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_008767809.4 → XP_008766031.2 disks large homolog 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMM3

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
XM_039085766.2 → XP_038941694.1 disks large homolog 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZMM3

Conserved Domains (5) summary

cd12030
Location:370 → 435

SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4

smart00228
Location:250 → 334

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

pfam00595
Location:5 → 89

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:473 → 651

Guanylate_kin; Guanylate kinase

pfam10600
Location:185 → 252

PDZ_assoc; PDZ-associated domain of NMDA receptors
XM_039085768.1 → XP_038941696.1 disks large homolog 4 isoform X4

UniProtKB/TrEMBL

A0A0G2K7F5

Related

ENSRNOP00000080495.2, ENSRNOT00000099685.2