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    Tmem199 transmembrane protein 199 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303332, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmem199provided by RGD
    Official Full Name
    transmembrane protein 199provided by RGD
    Primary source
    RGD:1566425
    See related
    EnsemblRapid:ENSRNOG00000009896 AllianceGenome:RGD:1566425
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxysterol binding activity. Predicted to be involved in cellular response to increased oxygen levels; intracellular monoatomic cation homeostasis; and lysosomal protein catabolic process. Predicted to be located in COPI-coated vesicle membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIp. Orthologous to human TMEM199 (transmembrane protein 199). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 188.1), Heart (RPKM 184.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tmem199 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63900543..63905115, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63402493..63407065, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65775721..65780293, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene vitronectin Neighboring gene SEBOX homeobox Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene TNF alpha induced protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC109028

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxysterol binding  
    enables oxysterol binding  
    Process Evidence Code Pubs
    involved_in cellular response to increased oxygen levels  
    involved_in cellular response to increased oxygen levels  
    involved_in cellular response to increased oxygen levels  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    involved_in intracellular iron ion homeostasis  
    involved_in lysosomal lumen acidification  
    involved_in lysosomal lumen acidification  
    involved_in lysosomal lumen acidification  
    involved_in lysosomal protein catabolic process  
    involved_in lysosomal protein catabolic process  
    involved_in lysosomal protein catabolic process  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle membrane  
    located_in COPI-coated vesicle membrane  
    located_in COPI-coated vesicle membrane  
    is_active_in endomembrane system  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in lysosome  
    part_of vacuolar proton-transporting V-type ATPase complex  
    part_of vacuolar proton-transporting V-type ATPase complex  
    part_of vacuolar proton-transporting V-type ATPase complex  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024992.1NP_001020163.1  transmembrane protein 199

      See identical proteins and their annotated locations for NP_001020163.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091246
      UniProtKB/Swiss-Prot
      Q5BK13
      UniProtKB/TrEMBL
      A0A8I6ALU1, A6HH56
      Related
      ENSRNOP00000013220.7, ENSRNOT00000013220.9
      Conserved Domains (1) summary
      pfam11712
      Location:78201
      Vma12; Endoplasmic reticulum-based factor for assembly of V-ATPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63900543..63905115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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