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    Tcf7 transcription factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363595, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tcf7provided by RGD
    Official Full Name
    transcription factor 7provided by RGD
    Primary source
    RGD:1305894
    See related
    EnsemblRapid:ENSRNOG00000005872 AllianceGenome:RGD:1305894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; cellular response to interleukin-4; and regulation of gamma-delta T cell differentiation. Predicted to act upstream of or within several processes, including T cell differentiation; embryonic morphogenesis; and neural tube development. Predicted to be located in euchromatin and nuclear body. Predicted to be part of beta-catenin-TCF complex. Orthologous to human TCF7 (transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 590.1), Spleen (RPKM 68.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Tcf7 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36924363..36954279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36423443..36454350, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37616033..37646027, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene protein FAM162A-like Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene S-phase kinase-associated protein 1 Neighboring gene voltage-dependent anion channel 1 Neighboring gene similar to human chromosome 5 open reading frame 15 Neighboring gene cytochrome b-c1 complex subunit 10-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell receptor V(D)J recombination  
    acts_upstream_of_or_within alpha-beta T cell differentiation  
    involved_in biological_process  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process  
    involved_in cellular response to interleukin-4  
    acts_upstream_of_or_within embryonic digestive tract morphogenesis  
    acts_upstream_of_or_within embryonic genitalia morphogenesis  
    acts_upstream_of_or_within embryonic hindgut morphogenesis  
    involved_in gamma-delta T cell differentiation  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within neural tube development  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of gamma-delta T cell differentiation  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex  
    located_in chromatin  
    located_in euchromatin  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    transcription factor 7
    Names
    transcription factor 7 (T-cell specific, HMG-box)
    transcription factor 7, T-cell specific

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427430.1 → NP_001414359.1  transcription factor 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A7R1, A0A8I6ASU6, A6HEA4
      Related
      ENSRNOP00000097383.1, ENSRNOT00000097186.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      36924363..36954279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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