Rnf145 ring finger protein 145 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf145provided by RGD
Official Full Name: ring finger protein 145provided by RGD
Primary source: RGD:1309561
See related: EnsemblRapid:ENSRNOG00000004602 AllianceGenome:RGD:1309561
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309561
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in endomembrane system. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 310.4), Lung (RPKM 289.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (29507779..29552153)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (29006391..29050788)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (30169147..30207505)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING finger protein 145

NP_001099248.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105778.3 → NP_001099248.1 RING finger protein 145

See identical proteins and their annotated locations for NP_001099248.1

Status: VALIDATED

Source sequence(s)

BC168651, CA503504, JAXUCZ010000010

UniProtKB/TrEMBL

B5DEF7, F7F591

Related

ENSRNOP00000006436.6, ENSRNOT00000006436.7

Conserved Domains (3) summary

COG5243
Location:520 → 643

HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]

cd16684
Location:533 → 575

RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins

pfam13705
Location:8 → 506

TRC8_N; TRC8 N-terminal domain