Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc5provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 5provided by RGD
Primary source: RGD:1589737
See related: EnsemblRapid:ENSRNOG00000006832 AllianceGenome:RGD:1589737
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DHHC-5
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in dendrite. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization, intracellular component. Orthologous to human ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 196.5), Kidney (RPKM 193.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90178734..90206889, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (69772037..69800142, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72090526..72118406, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
Title: The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway.
DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization.
Title: Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
this study identified the first neuronal DHHC5/8 substrate, define novel mechanisms controlling palmitoylation specificity, and suggest further links between dysregulated palmitoylation and neuropathological conditions.
Title: Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to phagocytic vesicle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pyroptotic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization, intracellular component	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: palmitoyltransferase ZDHHC5

Names: membrane-associated DHHC5 zinc finger protein; probable palmitoyltransferase ZDHHC5; zinc finger DHHC domain-containing protein 5; zinc finger, DHHC domain containing 5; zinc finger, DHHC-type containing 5

NP_001034427.1

EC 2.3.1.225

XP_017447385.1

EC 2.3.1.225

XP_017447386.1

EC 2.3.1.225

XP_017447387.1

EC 2.3.1.225

XP_038961338.1

EC 2.3.1.225

XP_063140208.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039338.1 → NP_001034427.1 palmitoyltransferase ZDHHC5

See identical proteins and their annotated locations for NP_001034427.1

Status: PROVISIONAL

Source sequence(s)

AY871203

UniProtKB/Swiss-Prot

Q2THW7

UniProtKB/TrEMBL

A6HMR0

Related

ENSRNOP00000009708.4, ENSRNOT00000009708.7

Conserved Domains (1) summary

pfam01529
Location:99 → 224

zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90178734..90206889 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591896.3 → XP_017447385.1 palmitoyltransferase ZDHHC5 isoform X1

UniProtKB/Swiss-Prot

Q2THW7

UniProtKB/TrEMBL

A6HMR0

Conserved Domains (1) summary

pfam01529
Location:99 → 224

zf-DHHC; DHHC palmitoyltransferase
XM_017591898.3 → XP_017447387.1 palmitoyltransferase ZDHHC5 isoform X1

UniProtKB/Swiss-Prot

Q2THW7

UniProtKB/TrEMBL

A6HMR0

Conserved Domains (1) summary

pfam01529
Location:99 → 224

zf-DHHC; DHHC palmitoyltransferase
XM_017591897.3 → XP_017447386.1 palmitoyltransferase ZDHHC5 isoform X1

UniProtKB/Swiss-Prot

Q2THW7

UniProtKB/TrEMBL

A6HMR0

Conserved Domains (1) summary

pfam01529
Location:99 → 224

zf-DHHC; DHHC palmitoyltransferase
XM_039105410.2 → XP_038961338.1 palmitoyltransferase ZDHHC5 isoform X2

UniProtKB/TrEMBL

A6HMR0

Conserved Domains (1) summary

pfam01529
Location:46 → 171

DHHC; DHHC palmitoyltransferase
XM_063284138.1 → XP_063140208.1 palmitoyltransferase ZDHHC5 isoform X1

UniProtKB/Swiss-Prot

Q2THW7

UniProtKB/TrEMBL

A6HMR0