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    Slc22a2 solute carrier family 22 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29503, updated on 4-Jan-2025

    Summary

    Official Symbol
    Slc22a2provided by RGD
    Official Full Name
    solute carrier family 22 member 2provided by RGD
    Primary source
    RGD:61936
    See related
    EnsemblRapid:ENSRNOG00000016625 AllianceGenome:RGD:61936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OCT2; OCT2r; rOCT2
    Summary
    Enables several functions, including monoamine transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including acetylcholine transport; histamine transport; and monoamine transport. Located in apical plasma membrane and basolateral plasma membrane. Is active in cholinergic synapse; presynaptic membrane; and synaptic vesicle membrane. Used to study acute kidney failure. Biomarker of cholestasis (multiple); hyperuricemia; and kidney failure (multiple). Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 601.3) See more
    Orthologs
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    Genomic context

    See Slc22a2 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50668817..50711019, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48121061..48163268, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48318025..48360219, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482693 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene solute carrier family 22 member 1 Neighboring gene uncharacterized LOC134484995 Neighboring gene protein LSM12 homolog pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 10 Neighboring gene uncharacterized LOC102553224

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 48
    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity  
    enables L-arginine transmembrane transporter activity  
    enables L-arginine transmembrane transporter activity  
    enables acetylcholine transmembrane transporter activity PubMed 
    enables acetylcholine transmembrane transporter activity  
    enables acetylcholine transmembrane transporter activity  
    enables amine transmembrane transporter activity  
    enables amine transmembrane transporter activity  
    enables choline transmembrane transporter activity PubMed 
    enables choline transmembrane transporter activity  
    enables choline transmembrane transporter activity  
    enables efflux transmembrane transporter activity  
    enables efflux transmembrane transporter activity  
    enables monoamine transmembrane transporter activity PubMed 
    enables monoamine transmembrane transporter activity  
    enables monoamine transmembrane transporter activity  
    enables monoamine transmembrane transporter activity  
    enables neurotransmitter transmembrane transporter activity PubMed 
    enables neurotransmitter transmembrane transporter activity  
    enables organic anion transmembrane transporter activity  
    enables organic anion transmembrane transporter activity  
    enables organic cation transmembrane transporter activity  
    enables organic cation transmembrane transporter activity PubMed 
    enables organic cation transmembrane transporter activity  
    enables prostaglandin transmembrane transporter activity  
    enables prostaglandin transmembrane transporter activity  
    enables prostaglandin transmembrane transporter activity  
    enables putrescine transmembrane transporter activity  
    enables putrescine transmembrane transporter activity  
    enables putrescine transmembrane transporter activity  
    enables pyrimidine nucleoside transmembrane transporter activity  
    enables pyrimidine nucleoside transmembrane transporter activity  
    enables quaternary ammonium group transmembrane transporter activity PubMed 
    enables quaternary ammonium group transmembrane transporter activity  
    enables quaternary ammonium group transmembrane transporter activity  
    enables spermidine transmembrane transporter activity  
    enables steroid binding PubMed 
    enables thiamine transmembrane transporter activity  
    enables thiamine transmembrane transporter activity  
    enables thiamine transmembrane transporter activity  
    enables toxin transmembrane transporter activity PubMed 
    enables toxin transmembrane transporter activity  
    enables toxin transmembrane transporter activity PubMed 
    enables toxin transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity PubMed 
    enables xenobiotic transmembrane transporter activity  
    enables xenobiotic transmembrane transporter activity  
    Items 1 - 25 of 48
    Items 1 - 25 of 63
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport  
    involved_in L-arginine import across plasma membrane  
    involved_in L-arginine import across plasma membrane  
    involved_in L-arginine transmembrane transport  
    involved_in acetylcholine transport PubMed 
    involved_in acetylcholine transport  
    involved_in acetylcholine transport  
    involved_in amine transport  
    involved_in amine transport  
    involved_in amino acid import across plasma membrane  
    involved_in cellular detoxification PubMed 
    involved_in cellular detoxification  
    involved_in cellular detoxification PubMed 
    involved_in cellular detoxification  
    involved_in choline transport  
    involved_in choline transport  
    involved_in dopamine transport PubMed 
    involved_in dopamine transport  
    involved_in dopamine uptake  
    involved_in dopamine uptake  
    involved_in epinephrine transport PubMed 
    involved_in epinephrine transport  
    involved_in epinephrine transport  
    involved_in export across plasma membrane  
    involved_in export across plasma membrane  
    involved_in histamine transport PubMed 
    involved_in histamine transport  
    involved_in histamine uptake  
    involved_in histamine uptake  
    involved_in monoatomic cation transport  
    acts_upstream_of_or_within monoatomic cation transport  
    involved_in neurotransmitter transport  
    involved_in norepinephrine transport PubMed 
    involved_in norepinephrine transport  
    involved_in norepinephrine uptake  
    involved_in norepinephrine uptake  
    involved_in organic cation transport  
    involved_in organic cation transport PubMed 
    acts_upstream_of_or_within organic cation transport  
    involved_in organic cation transport  
    involved_in prostaglandin transport  
    involved_in prostaglandin transport  
    involved_in prostaglandin transport  
    involved_in putrescine transport  
    involved_in putrescine transport  
    involved_in putrescine transport  
    involved_in quaternary ammonium group transport PubMed 
    involved_in quaternary ammonium group transport  
    involved_in serotonin transport PubMed 
    involved_in serotonin transport  
    involved_in serotonin transport  
    involved_in serotonin uptake  
    involved_in serotonin uptake  
    involved_in spermidine transmembrane transport  
    involved_in spermidine transport  
    involved_in thiamine transmembrane transport  
    involved_in thiamine transmembrane transport  
    involved_in thiamine transmembrane transport  
    involved_in xenobiotic transport PubMed 
    involved_in xenobiotic transport  
    involved_in xenobiotic transport PubMed 
    involved_in xenobiotic transport  
    involved_in xenobiotic transport across blood-brain barrier PubMed 
    Items 1 - 25 of 63
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in basal plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    is_active_in cholinergic synapse PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in presynapse  
    is_active_in presynaptic membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 

    General protein information

    Preferred Names
    solute carrier family 22 member 2
    Names
    organic cation transporter 2
    solute carrier family 22 (organic cation transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031584.2NP_113772.1  solute carrier family 22 member 2

      See identical proteins and their annotated locations for NP_113772.1

      Status: PROVISIONAL

      Source sequence(s)
      D83044
      UniProtKB/Swiss-Prot
      P70485, P97558, Q9R0W2
      UniProtKB/TrEMBL
      A0A0G2JSP9, A6KJX5
      Related
      ENSRNOP00000023116.2, ENSRNOT00000023116.7
      Conserved Domains (2) summary
      cd06174
      Location:125492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      50668817..50711019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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