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    Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83572, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pafah1b1provided by RGD
    Official Full Name
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1provided by RGD
    Primary source
    RGD:620331
    See related
    EnsemblRapid:ENSRNOG00000002755 AllianceGenome:RGD:620331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LIS1
    Summary
    Enables dynein intermediate chain binding activity. Involved in several processes, including establishment of centrosome localization; generation of neurons; and regulation of neuron projection development. Located in several cellular components, including central region of growth cone; neuronal cell body; and nuclear envelope. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex and kinesin complex. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 940.0), Adrenal (RPKM 502.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pafah1b1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60031441..60090259, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59533042..59591808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61456144..61577412, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit e, mitochondrial-like Neighboring gene uncharacterized LOC134480822 Neighboring gene clustered mitochondria homolog Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein complex binding  
    enables dynein complex binding  
    enables dynein intermediate chain binding PubMed 
    enables identical protein binding  
    enables microtubule binding  
    enables microtubule plus-end binding  
    enables phosphoprotein binding  
    enables platelet-activating factor acetyltransferase activity PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    acts_upstream_of JNK cascade  
    acts_upstream_of_or_within acrosome assembly  
    acts_upstream_of_or_within actin cytoskeleton organization  
    acts_upstream_of_or_within adult locomotory behavior  
    involved_in adult locomotory behavior  
    acts_upstream_of_or_within ameboidal-type cell migration  
    involved_in auditory receptor cell development  
    involved_in brain morphogenesis  
    involved_in brain morphogenesis  
    acts_upstream_of_or_within cell migration  
    acts_upstream_of_or_within cerebral cortex development  
    involved_in cerebral cortex development  
    involved_in cerebral cortex neuron differentiation PubMed 
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in cochlea development  
    involved_in corpus callosum morphogenesis  
    involved_in cortical microtubule organization  
    involved_in establishment of centrosome localization PubMed 
    acts_upstream_of_or_within establishment of localization in cell  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of planar polarity of embryonic epithelium  
    involved_in germ cell development  
    acts_upstream_of_or_within hippocampus development  
    acts_upstream_of_or_within interneuron migration  
    acts_upstream_of_or_within layer formation in cerebral cortex  
    acts_upstream_of_or_within learning or memory  
    involved_in lipid catabolic process  
    acts_upstream_of_or_within maintenance of centrosome location  
    acts_upstream_of_or_within microtubule cytoskeleton organization  
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity  
    involved_in microtubule organizing center organization  
    involved_in microtubule organizing center organization  
    involved_in microtubule sliding  
    involved_in microtubule-based process  
    involved_in modulation of chemical synaptic transmission  
    acts_upstream_of_or_within myeloid leukocyte migration  
    acts_upstream_of_or_within negative regulation of JNK cascade  
    involved_in negative regulation of neuron projection development PubMed 
    acts_upstream_of_or_within neuroblast proliferation  
    acts_upstream_of_or_within neuromuscular process controlling balance  
    involved_in neuromuscular process controlling balance  
    involved_in neuron migration PubMed 
    acts_upstream_of_or_within neuron migration  
    involved_in neuron migration  
    acts_upstream_of_or_within nuclear membrane disassembly  
    involved_in nuclear migration  
    involved_in nuclear migration PubMed 
    acts_upstream_of_or_within osteoclast development  
    involved_in positive regulation of axon extension PubMed 
    involved_in positive regulation of cellular component organization  
    acts_upstream_of_or_within positive regulation of cytokine-mediated signaling pathway  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of embryonic development  
    involved_in positive regulation of mitotic cell cycle PubMed 
    acts_upstream_of_or_within protein secretion  
    acts_upstream_of_or_within radial glia-guided pyramidal neuron migration  
    involved_in reelin-mediated signaling pathway  
    involved_in reelin-mediated signaling pathway  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of postsynapse organization  
    involved_in retrograde axonal transport  
    acts_upstream_of_or_within retrograde axonal transport  
    involved_in stem cell division PubMed 
    acts_upstream_of_or_within transmission of nerve impulse  
    involved_in vesicle transport along microtubule  
    acts_upstream_of_or_within vesicle transport along microtubule  
    Items 1 - 25 of 67
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex PubMed 
    part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in astral microtubule  
    located_in axon PubMed 
    located_in axon cytoplasm  
    located_in cell cortex  
    located_in cell leading edge  
    located_in central region of growth cone PubMed 
    located_in centrosome  
    located_in cytoplasm  
    is_active_in cytoplasmic microtubule  
    is_active_in glutamatergic synapse  
    located_in growth cone PubMed 
    part_of kinesin complex PubMed 
    is_active_in kinetochore  
    located_in kinetochore  
    part_of microtubule associated complex  
    part_of microtubule associated complex  
    located_in microtubule cytoskeleton  
    located_in motile cilium  
    is_active_in neuron projection  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    NOT located_in non-motile cilium  
    is_active_in nuclear envelope  
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear membrane  
    located_in perinuclear region of cytoplasm  
    located_in stereocilium  
    located_in vesicle PubMed 
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha
    Names
    LIS-1
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAF-AH beta
    PAFAH alpha
    lissencephaly-1 protein
    platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)
    NP_113951.1
    XP_038942872.1
    XP_063126033.1
    XP_063126034.1
    XP_063126035.1
    XP_063126036.1
    XP_063126037.1
    XP_063126038.1
    XP_063126039.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031763.3NP_113951.1  platelet-activating factor acetylhydrolase IB subunit alpha

      See identical proteins and their annotated locations for NP_113951.1

      Status: PROVISIONAL

      Source sequence(s)
      BC072510
      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
      Related
      ENSRNOP00000003696.4, ENSRNOT00000003696.8
      Conserved Domains (3) summary
      cd00200
      Location:104408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:1034
      LisH

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60031441..60090259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269964.1XP_063126034.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    2. XM_063269963.1XP_063126033.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    3. XM_063269967.1XP_063126037.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    4. XM_039086944.2XP_038942872.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
      Conserved Domains (3) summary
      cd00200
      Location:104408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:1034
      LisH
    5. XM_063269965.1XP_063126035.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    6. XM_063269968.1XP_063126038.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    7. XM_063269966.1XP_063126036.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
    8. XM_063269969.1XP_063126039.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      O35592, P43035, P63004, P81692, Q9R2A6
      UniProtKB/TrEMBL
      A6HGN1
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