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    Adgrg6 adhesion G protein-coupled receptor G6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308376, updated on 27-Dec-2024

    Summary

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    Symbol
    Adgrg6provided by RGD
    Full Name
    adhesion G protein-coupled receptor G6provided by RGD
    Primary source
    RGD:1308551
    See related
    EnsemblRapid:ENSRNOG00000011411 AllianceGenome:RGD:1308551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr126
    Summary
    Predicted to enable G protein-coupled receptor activity and laminin binding activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart trabecula formation; and myelination in peripheral nervous system. Predicted to be located in cell surface and cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 190.4), Spleen (RPKM 83.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrg6 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (10633004..10774685, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (8812889..8954239, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (8593342..8751540, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 38 Neighboring gene uncharacterized LOC134484949 Neighboring gene uncharacterized LOC108349488 Neighboring gene vesicle trafficking 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures. Damasceno S, et al. Epilepsy Res, 2018 Nov. PMID 30193173
    2. Mutations of GPR126 are responsible for severe arthrogryposis multiplex congenita. Ravenscroft G, et al. Am J Hum Genet, 2015 Jun 4. PMID 26004201, Free PMC Article
    3. VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells. Stehlik C, et al. FEBS Lett, 2004 Jul 2. PMID 15225624
    4. Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys. Kösters P, et al. Cells, 2024 May 18. PMID 38786096, Free PMC Article
    5. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Moriguchi T, et al. Genes Cells, 2004 Jun. PMID 15189448

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
      Title: Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
    2. This study verified that the WAR model shows down-regulation of Gpr126 in the corpus quadrigeminum.
      Title: Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Schwann cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heart trabecula formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart trabecula formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination in peripheral nervous system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G6
    Names
    G-protein coupled receptor 126

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427850.1 → NP_001414779.1  adhesion G-protein coupled receptor G6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5Y9J5, A0A8I6ALS0
      Related
      ENSRNOP00000095596.2, ENSRNOT00000108246.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      10633004..10774685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261282.1 → XP_063117352.1  adhesion G-protein coupled receptor G6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9J5

    2. XM_218313.11 → XP_218313.7  adhesion G-protein coupled receptor G6 isoform X1

      See identical proteins and their annotated locations for XP_218313.7

      UniProtKB/TrEMBL
      A0A0G2JST1, A0A8I5Y9J5
      Related
      ENSRNOP00000029263.7, ENSRNOT00000030511.8
      Conserved Domains (4) summary
      cd00041
      Location:38 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:799 → 844
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:861 → 1108
      7tm_4; Olfactory receptor
      cl22861
      Location:178 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. XM_039098598.2 → XP_038954526.1  adhesion G-protein coupled receptor G6 isoform X5

      Conserved Domains (3) summary
      pfam01825
      Location:389 → 434
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:451 → 476
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:449 → 717
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_017589821.3 → XP_017445310.1  adhesion G-protein coupled receptor G6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9J5
      Related
      ENSRNOP00000094336.2, ENSRNOT00000109442.2

    5. XM_017589822.3 → XP_017445311.1  adhesion G-protein coupled receptor G6 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9J5, A0A8I6ALD7
      Related
      ENSRNOP00000077463.2, ENSRNOT00000099051.2
    Nucleotide Protein Strain
    Heading Accession and Version

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