Cenpa centromere protein A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpaprovided by RGD
Official Full Name: centromere protein Aprovided by RGD
Primary source: RGD:1563607
See related: EnsemblRapid:ENSRNOG00000071944 AllianceGenome:RGD:1563607
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563607
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in centromere complex assembly; establishment of mitotic spindle orientation; and mitotic cytokinesis. Predicted to act upstream of or within protein localization to chromosome, centromeric region. Predicted to be located in chromosome, centromeric region and nucleoplasm. Predicted to be part of CENP-A containing nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human CENPA (centromere protein A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 95.9), Spleen (RPKM 63.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31420062..31431703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25700142..25711767, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (27072259..27080863, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI045252 (e-PCR)
- UniSTS:248392

RH143311 (e-PCR)
- UniSTS:232558

RH141436 (e-PCR)
- UniSTS:223430

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, centromeric region	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in CENP-A containing chromatin	ISO Inferred from Sequence Orthology more info
part_of CENP-A containing nucleosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H3-like centromeric protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106711.1 → NP_001100181.1 histone H3-like centromeric protein A

See identical proteins and their annotated locations for NP_001100181.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HAC7, B2RZ23, F7EQM2

Conserved Domains (3) summary

smart00428
Location:59 → 156

H3; Histone H3

pfam00125
Location:29 → 152

Histone; Core histone H2A/H2B/H3/H4

pfam15091
Location:5 → 73

DUF4554; Domain of unknown function (DUF4554)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

31420062..31431703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239798.5 → XP_006239860.1 histone H3-like centromeric protein A isoform X1

See identical proteins and their annotated locations for XP_006239860.1

UniProtKB/TrEMBL

A6HAC7, B2RZ23, F7EQM2

Related

ENSRNOP00000103779.1, ENSRNOT00000166400.1

Conserved Domains (3) summary

smart00428
Location:59 → 156

H3; Histone H3

pfam00125
Location:29 → 152

Histone; Core histone H2A/H2B/H3/H4

pfam15091
Location:5 → 73

DUF4554; Domain of unknown function (DUF4554)
XM_017594068.3 → XP_017449557.1 histone H3-like centromeric protein A isoform X2

UniProtKB/TrEMBL

A6HAC8