U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cd8a CD8 subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24930, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd8aprovided by RGD
    Official Full Name
    CD8 subunit alphaprovided by RGD
    Primary source
    RGD:2316
    See related
    EnsemblRapid:ENSRNOG00000007178 AllianceGenome:RGD:2316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase binding activity. Involved in response to methamphetamine hydrochloride. Located in cell surface. Biomarker of amphetamine abuse and brain infarction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CD8A (CD8 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1790.2), Spleen (RPKM 183.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd8a in Genome Data Viewer
    Location:
    4q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (104924116..104928353)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103365804..103370041)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99217640..99243352)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486799 Neighboring gene CD8 subunit beta Neighboring gene tubulin, alpha 1B, pseudogene 8 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene transfer RNA serine (anticodon AGA) 32 Neighboring gene ring finger protein 103

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft  
    part_of receptor complex  

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8 antigen 32 kDa chain
    CD8 antigen, alpha-chain
    CD8a molecule
    OX-8 membrane antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031538.2NP_113726.1  T-cell surface glycoprotein CD8 alpha chain precursor

      See identical proteins and their annotated locations for NP_113726.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088126
      UniProtKB/Swiss-Prot
      P07725
      UniProtKB/TrEMBL
      A6IA73
      Related
      ENSRNOP00000106503.1, ENSRNOT00000161718.1
      Conserved Domains (2) summary
      smart00410
      Location:32131
      IG_like; Immunoglobulin like
      cl11960
      Location:36137
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      104924116..104928353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.