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    Stt3a STT3 oligosaccharyltransferase complex catalytic subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500972, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stt3aprovided by RGD
    Official Full Name
    STT3 oligosaccharyltransferase complex catalytic subunit Aprovided by RGD
    Primary source
    RGD:1565793
    See related
    EnsemblRapid:ENSRNOG00000031896 AllianceGenome:RGD:1565793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Itm1; RGD1565793
    Summary
    Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in co-translational protein modification and protein N-linked glycosylation via asparagine. Predicted to be located in membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 283.6), Kidney (RPKM 231.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stt3a in Genome Data Viewer
    Location:
    8q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (44632473..44671960, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (36443623..36483111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39204218..39243751, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene acrosomal vesicle protein 1 Neighboring gene checkpoint kinase 1 Neighboring gene EI24, autophagy associated transmembrane protein Neighboring gene fasciculation and elongation protein zeta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC188229

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane  
    part_of oligosaccharyltransferase complex  

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
    Names
    STT3, subunit of the oligosaccharyltransferase complex, homolog A
    STT3A, catalytic subunit of the oligosaccharyltransferase complex
    STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
    integral membrane protein 1
    integral transmembrane protein 1
    NP_001128221.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134749.3NP_001128221.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

      See identical proteins and their annotated locations for NP_001128221.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KRN0, B4F7C9, F1LM63
      Related
      ENSRNOP00000097342.1, ENSRNOT00000096876.2
      Conserved Domains (1) summary
      pfam02516
      Location:17484
      STT3; Oligosaccharyl transferase STT3 subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      44632473..44671960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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