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    Psmb4 proteasome 20S subunit beta 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb4provided by RGD
    Official Full Name
    proteasome 20S subunit beta 4provided by RGD
    Primary source
    RGD:61877
    See related
    AllianceGenome:RGD:61877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in negative regulation of inflammatory response to antigenic stimulus and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in ciliary basal body; mitochondrion; and nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1319.9), Thymus (RPKM 1188.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psmb4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185131787..185134561, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182442757..182445532, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196043546..196046320, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 2 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene high mobility group protein B1 pseudogene Neighboring gene small nucleolar RNA U89 Neighboring gene selenium binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in ciliary basal body  
    located_in ciliary basal body  
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    part_of proteasome complex  
    part_of proteasome core complex  
    part_of proteasome core complex  
    part_of proteasome core complex  
    part_of proteasome core complex, beta-subunit complex  
    part_of proteasome core complex, beta-subunit complex  

    General protein information

    Preferred Names
    proteasome subunit beta type-4
    Names
    RN3
    beta-7
    macropain beta chain
    multicatalytic endopeptidase complex beta chain
    proteasome (prosome, macropain) subunit, beta type 4
    proteasome beta 4 subunit
    proteasome beta chain
    proteasome chain 3
    proteasome subunit beta 4
    proteasome subunit beta-7
    NP_113817.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031629.2NP_113817.2  proteasome subunit beta type-4

      See identical proteins and their annotated locations for NP_113817.2

      Status: VALIDATED

      Source sequence(s)
      FQ232850
      UniProtKB/Swiss-Prot
      P28071, P34067, P97719
      UniProtKB/TrEMBL
      A6K2T2
      Conserved Domains (2) summary
      COG0638
      Location:45241
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03760
      Location:52247
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185131787..185134561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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