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    Zmiz2 zinc finger, MIZ-type containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289783, updated on 9-Dec-2024

    Summary

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    Symbol
    Zmiz2provided by RGD
    Full Name
    zinc finger, MIZ-type containing 2provided by RGD
    Primary source
    RGD:1309256
    See related
    EnsemblRapid:ENSRNOG00000025923 AllianceGenome:RGD:1309256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309256
    Summary
    Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to be located in chromatin; mitochondrion; and nuclear lumen. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 51.3), Thymus (RPKM 43.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zmiz2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85465323..85481860)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81251391..81267936)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86645875..86662419)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) 26 Neighboring gene oxoglutarate dehydrogenase Neighboring gene U4 spliceosomal RNA Neighboring gene small Cajal body-specific RNA 16 Neighboring gene peptidylprolyl isomerase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Huang CY, et al. Mol Endocrinol, 2005 Dec. PMID 16051670
    2. The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity. Li X, et al. J Biol Chem, 2006 Aug 18. PMID 16777850
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MIZ domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100507.1 → NP_001093977.1  zinc finger MIZ domain-containing protein 2

      See identical proteins and their annotated locations for NP_001093977.1

      Status: VALIDATED

      Source sequence(s)
      AW528357, BC079401, CK364743, CK473991, CV111150, DY312973, JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IKT5, G3V9C9
      Related
      ENSRNOP00000042684.3, ENSRNOT00000052002.6
      Conserved Domains (2) summary
      PHA03378
      Location:683 → 886
      PHA03378; EBNA-3B; Provisional
      cd16791
      Location:597 → 644
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      85465323..85481860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272960.1 → XP_063129030.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    2. XM_063272957.1 → XP_063129027.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    3. XM_063272967.1 → XP_063129037.1  zinc finger MIZ domain-containing protein 2 isoform X3

    4. XM_063272969.1 → XP_063129039.1  zinc finger MIZ domain-containing protein 2 isoform X4

    5. XM_063272965.1 → XP_063129035.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6IKT5, G3V9C9

    6. XM_039091751.2 → XP_038947679.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6IKT5, G3V9C9
      Conserved Domains (2) summary
      PHA03378
      Location:683 → 886
      PHA03378; EBNA-3B; Provisional
      cd16791
      Location:597 → 644
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    7. XM_063272970.1 → XP_063129040.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A6IKT6
      Related
      ENSRNOP00000099615.1, ENSRNOT00000139159.1

    8. XM_063272963.1 → XP_063129033.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    9. XM_063272961.1 → XP_063129031.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    10. XM_063272972.1 → XP_063129042.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A6IKT6

    11. XM_063272959.1 → XP_063129029.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    12. XM_017599125.3 → XP_017454614.1  zinc finger MIZ domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JUU0
      Related
      ENSRNOP00000069227.2, ENSRNOT00000077428.3
      Conserved Domains (1) summary
      pfam02891
      Location:570 → 618
      zf-MIZ; MIZ/SP-RING zinc finger

    13. XM_063272968.1 → XP_063129038.1  zinc finger MIZ domain-containing protein 2 isoform X4

    14. XM_006251440.5 → XP_006251502.1  zinc finger MIZ domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006251502.1

      UniProtKB/TrEMBL
      A6IKT6
      Conserved Domains (1) summary
      pfam02891
      Location:564 → 612
      zf-MIZ; MIZ/SP-RING zinc finger

    15. XM_008770269.4 → XP_008768491.1  zinc finger MIZ domain-containing protein 2 isoform X7

      See identical proteins and their annotated locations for XP_008768491.1

      Conserved Domains (1) summary
      pfam02891
      Location:538 → 586
      zf-MIZ; MIZ/SP-RING zinc finger

    16. XM_063272974.1 → XP_063129044.1  zinc finger MIZ domain-containing protein 2 isoform X8

    17. XM_063272971.1 → XP_063129041.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A6IKT6
      Related
      ENSRNOP00000081352.2, ENSRNOT00000108819.2

    18. XM_063272973.1 → XP_063129043.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A6IKT6

    19. XM_063272962.1 → XP_063129032.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9

    20. XM_063272966.1 → XP_063129036.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6IKT5, G3V9C9

    21. XM_063272958.1 → XP_063129028.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRF9
    Nucleotide Protein Strain
    Heading Accession and Version

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