U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cxcl9 C-X-C motif chemokine ligand 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246759, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cxcl9provided by RGD
    Official Full Name
    C-X-C motif chemokine ligand 9provided by RGD
    Primary source
    RGD:628798
    See related
    EnsemblRapid:ENSRNOG00000022242 AllianceGenome:RGD:628798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mig; Scyb9
    Summary
    Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; neutrophil chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 145.4), Muscle (RPKM 120.4) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cxcl9 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16007166..16012077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15722868..15727779)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17228832..17233743)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 3 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene SDA1 domain containing 1 Neighboring gene N-acylethanolamine acid amidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC105312

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding  
    enables CXCR3 chemokine receptor binding  
    enables CXCR3 chemokine receptor binding PubMed 
    enables chemokine activity  
    enables chemokine activity  
    enables chemokine activity PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in cellular response to lipopolysaccharide  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemotaxis  
    acts_upstream_of_or_within defense response to virus  
    involved_in induction of positive chemotaxis PubMed 
    involved_in inflammatory response  
    involved_in neutrophil chemotaxis  
    acts_upstream_of_or_within positive regulation of myoblast differentiation  
    acts_upstream_of_or_within positive regulation of myoblast fusion  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within response to bacterium  
    Component Evidence Code Pubs
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    C-X-C motif chemokine 9
    Names
    chemokine (C-X-C motif) ligand 9
    monokine induced by gamma interferon
    small inducible cytokine B9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145672.4 → NP_663705.1  C-X-C motif chemokine 9 precursor

      See identical proteins and their annotated locations for NP_663705.1

      Status: PROVISIONAL

      Source sequence(s)
      AF537208
      UniProtKB/TrEMBL
      A6KK93, F7F001, Q8K4B1
      Related
      ENSRNOP00000003627.4, ENSRNOT00000003082.9
      Conserved Domains (1) summary
      cd00273
      Location:29 → 89
      Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16007166..16012077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.