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    MRPL55 mitochondrial ribosomal protein L55 [ Homo sapiens (human) ]

    Gene ID: 128308, updated on 4-Jan-2025

    Summary

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    Official Symbol
    MRPL55provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L55provided by HGNC
    Primary source
    HGNC:HGNC:16686
    See related
    Ensembl:ENSG00000162910 MIM:611859; AllianceGenome:HGNC:16686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L55nt; bL31m; MRP-L55; AAVG5835; PRO19675
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.8), prostate (RPKM 8.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRPL55 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228106685..228109299, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227295671..227315175, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228294386..228297000, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ARF GTPase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:228284937-228286136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2689 Neighboring gene microRNA 3620 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289072-228289792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289793-228290512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228290513-228291233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228291234-228291953 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228295219-228295933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228295934-228296647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1913 Neighboring gene CIAO2A pseudogene 2 Neighboring gene ribosomal protein S28 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. O'Brien TW. Gene, 2002 Mar 6. PMID 11943462
    2. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
    3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
    4. The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia. Amhaz S, et al. BMC Biol, 2023 Apr 7. PMID 37024974, Free PMC Article
    5. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC61802, DKFZp686D1387

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL55
    Names
    39S ribosomal protein L55, mitochondrial
    L55mt
    mitochondrial large ribosomal subunit protein bL31m
    mitochondrial large ribosomal subunit protein mL55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321284.2 → NP_001308213.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Source sequence(s)
      BC052806, BQ011059, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355708.3, ENST00000366747.7
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    2. NM_181441.3 → NP_852106.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks a segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BM975134, BP871687, BQ012917, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000338189.5, ENST00000348259.9
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    3. NM_181454.3 → NP_852119.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BF945771, BM706934, BQ012917, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355700.1, ENST00000366739.5
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    4. NM_181455.3 → NP_852120.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BF945771, BM706934, BQ012917, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000375740.3, ENST00000391867.8
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    5. NM_181456.3 → NP_852121.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks one segment and contains an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BI458525, BQ012917, BU597178
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000337361.5, ENST00000336300.9
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    6. NM_181462.3 → NP_852127.2  large ribosomal subunit protein mL55 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate in-frame segment when compared to variant 5. The predicted protein (isoform b) is longer than isoform a. The predicted ORF of this transcript has not been experimentally confirmed.
      Source sequence(s)
      AY358771, BI458525, BQ012917
      Consensus CDS
      CCDS44325.1
      UniProtKB/Swiss-Prot
      Q7Z7F7
      Related
      ENSP00000403614.1, ENST00000430433.5
      Conserved Domains (1) summary
      pfam09776
      Location:47 → 161
      Mitoc_L55; Mitochondrial ribosomal protein L55

    7. NM_181463.3 → NP_852128.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is the most commonly occurring transcript. Variants 1, 2, 3, 5, 6, 7, 8 encode the same isoform (a).
      Source sequence(s)
      BI458525, BQ012917, BU601595
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000337342.3, ENST00000336520.8
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    8. NM_181464.3 → NP_852129.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses a different splice site in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BQ012917, BU594505, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000295008.4, ENST00000295008.8
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    9. NM_181465.3 → NP_852130.1  large ribosomal subunit protein mL55 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses a different splice site in one segment and lacks an additional segment in the 5' UTR when compared to variant 5. Variants 1, 2, 3, 5, 6, 7, and 8 encode the same isoform (a).
      Source sequence(s)
      BQ012917, BU597178, CV572808
      Consensus CDS
      CCDS1567.1
      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355707.3, ENST00000366746.7
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      228106685..228109299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446137.1 → XP_047302093.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    2. XM_047446143.1 → XP_047302099.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    3. XM_047446133.1 → XP_047302089.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    4. XM_005273062.4 → XP_005273119.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355703.1, ENST00000366742.5
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    5. XM_047446139.1 → XP_047302095.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    6. XM_047446096.1 → XP_047302052.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355695.1, ENST00000366734.5

    7. XM_047446113.1 → XP_047302069.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    8. XM_047446123.1 → XP_047302079.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355705.1, ENST00000366744.5

    9. XM_047446106.1 → XP_047302062.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    10. XM_005273061.6 → XP_005273118.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    11. XM_047446095.1 → XP_047302051.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    12. XM_047446098.1 → XP_047302054.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    13. XM_005273063.6 → XP_005273120.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    14. XM_011544095.4 → XP_011542397.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    15. XM_047446079.1 → XP_047302035.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    16. XM_005273059.4 → XP_005273116.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
      Related
      ENSP00000355694.1, ENST00000366733.5
      Conserved Domains (1) summary
      pfam09776
      Location:11 → 125
      Mitoc_L55; Mitochondrial ribosomal protein L55

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227295671..227315175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334443.1 → XP_054190418.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    2. XM_054334446.1 → XP_054190421.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    3. XM_054334448.1 → XP_054190423.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    4. XM_054334445.1 → XP_054190420.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    5. XM_054334440.1 → XP_054190415.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    6. XM_054334447.1 → XP_054190422.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    7. XM_054334438.1 → XP_054190413.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    8. XM_054334442.1 → XP_054190417.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    9. XM_054334444.1 → XP_054190419.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    10. XM_054334441.1 → XP_054190416.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    11. XM_054334434.1 → XP_054190409.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    12. XM_054334437.1 → XP_054190412.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    13. XM_054334439.1 → XP_054190414.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    14. XM_054334433.1 → XP_054190408.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    15. XM_054334436.1 → XP_054190411.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    16. XM_054334432.1 → XP_054190407.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    17. XM_054334435.1 → XP_054190410.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7

    18. XM_054334431.1 → XP_054190406.1  large ribosomal subunit protein mL55 isoform X1

      UniProtKB/Swiss-Prot
      Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7F7.1 GenPept UniProtKB/Swiss-Prot:Q7Z7F7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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