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    WNK4 WNK lysine deficient protein kinase 4 [ Homo sapiens (human) ]

    Gene ID: 65266, updated on 4-Jan-2025

    Summary

    Official Symbol
    WNK4provided by HGNC
    Official Full Name
    WNK lysine deficient protein kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:14544
    See related
    Ensembl:ENSG00000126562 MIM:601844; AllianceGenome:HGNC:14544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PHA2B; PRKWNK4
    Summary
    This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in kidney (RPKM 12.8), prostate (RPKM 5.7) and 6 other tissues See more
    Orthologs
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    Genomic context

    See WNK4 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42780610..42797066)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43637750..43654206)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40932628..40949084)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAMP2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8547 Neighboring gene receptor activity modifying protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40925642-40926189 Neighboring gene Sharpr-MPRA regulatory region 12532 Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40932701-40933658 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:40934948-40936147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12225 Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables chloride ion binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables ion channel inhibitor activity  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 28
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade  
    involved_in aldosterone secretion  
    involved_in calcium ion homeostasis  
    involved_in cellular response to xenobiotic stimulus  
    involved_in chloride transport  
    involved_in chromatin remodeling  
    involved_in distal tubule morphogenesis PubMed 
    involved_in gene expression  
    involved_in inflammatory response  
    involved_in intracellular chloride ion homeostasis  
    involved_in intracellular signal transduction  
    involved_in macrophage activation  
    involved_in monoatomic ion homeostasis PubMed 
    involved_in negative regulation of pancreatic juice secretion  
    involved_in negative regulation of protein localization to plasma membrane  
    involved_in negative regulation of sodium ion transport  
    involved_in potassium ion transmembrane transport  
    involved_in protein localization  
    involved_in protein phosphorylation  
    involved_in regulation of blood pressure  
    involved_in regulation of potassium ion export across plasma membrane  
    involved_in renal sodium ion absorption PubMed 
    involved_in renal sodium ion absorption PubMed 
    involved_in renal sodium ion transport  
    involved_in response to dietary excess  
    involved_in signal transduction  
    involved_in sodium ion transmembrane transport  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in bicellular tight junction PubMed 
    located_in bicellular tight junction  
    located_in cell body  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in membrane  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    serine/threonine-protein kinase WNK4
    Names
    protein kinase lysine-deficient 4
    protein kinase with no lysine 4
    NP_001308228.1
    NP_115763.2
    XP_016880451.1
    XP_016880455.1
    XP_047292510.1
    XP_047292512.1
    XP_047292513.1
    XP_047292514.1
    XP_047292515.1
    XP_047292516.1
    XP_047292517.1
    XP_047292518.1
    XP_047292519.1
    XP_054172926.1
    XP_054172927.1
    XP_054172928.1
    XP_054172929.1
    XP_054172930.1
    XP_054172931.1
    XP_054172932.1
    XP_054172933.1
    XP_054172934.1
    XP_054172935.1
    XP_054172936.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016227.1 RefSeqGene

      Range
      4980..21436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321299.2 → NP_001308228.1  serine/threonine-protein kinase WNK4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC100793, BC144356, BM683764, CA388932
      Conserved Domains (1) summary
      pfam12202
      Location:117 → 153
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    2. NM_032387.5 → NP_115763.2  serine/threonine-protein kinase WNK4 isoform 1

      See identical proteins and their annotated locations for NP_115763.2

      Status: REVIEWED

      Source sequence(s)
      AC100793, BC136664, BM683764, CA388932
      Consensus CDS
      CCDS11439.1
      UniProtKB/Swiss-Prot
      B0LPI0, Q8N8X3, Q8N8Z2, Q96DT8, Q96J92, Q9BYS5
      Related
      ENSP00000246914.4, ENST00000246914.10
      Conserved Domains (3) summary
      smart00220
      Location:179 → 432
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14033
      Location:172 → 432
      STKc_WNK4; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4
      pfam12202
      Location:453 → 489
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42780610..42797066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024962.2 → XP_016880451.1  serine/threonine-protein kinase WNK4 isoform X1

    2. XM_047436559.1 → XP_047292515.1  serine/threonine-protein kinase WNK4 isoform X6

    3. XM_047436554.1 → XP_047292510.1  serine/threonine-protein kinase WNK4 isoform X2

    4. XM_047436558.1 → XP_047292514.1  serine/threonine-protein kinase WNK4 isoform X5

    5. XM_047436560.1 → XP_047292516.1  serine/threonine-protein kinase WNK4 isoform X7

    6. XM_047436556.1 → XP_047292512.1  serine/threonine-protein kinase WNK4 isoform X3

    7. XM_047436561.1 → XP_047292517.1  serine/threonine-protein kinase WNK4 isoform X8

    8. XM_047436563.1 → XP_047292519.1  serine/threonine-protein kinase WNK4 isoform X10

    9. XM_047436557.1 → XP_047292513.1  serine/threonine-protein kinase WNK4 isoform X4

    10. XM_047436562.1 → XP_047292518.1  serine/threonine-protein kinase WNK4 isoform X9

    11. XM_017024966.2 → XP_016880455.1  serine/threonine-protein kinase WNK4 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43637750..43654206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316951.1 → XP_054172926.1  serine/threonine-protein kinase WNK4 isoform X1

    2. XM_054316956.1 → XP_054172931.1  serine/threonine-protein kinase WNK4 isoform X6

    3. XM_054316952.1 → XP_054172927.1  serine/threonine-protein kinase WNK4 isoform X2

    4. XM_054316955.1 → XP_054172930.1  serine/threonine-protein kinase WNK4 isoform X5

    5. XM_054316957.1 → XP_054172932.1  serine/threonine-protein kinase WNK4 isoform X7

    6. XM_054316953.1 → XP_054172928.1  serine/threonine-protein kinase WNK4 isoform X3

    7. XM_054316958.1 → XP_054172933.1  serine/threonine-protein kinase WNK4 isoform X8

    8. XM_054316960.1 → XP_054172935.1  serine/threonine-protein kinase WNK4 isoform X10

    9. XM_054316954.1 → XP_054172929.1  serine/threonine-protein kinase WNK4 isoform X4

    10. XM_054316959.1 → XP_054172934.1  serine/threonine-protein kinase WNK4 isoform X9

    11. XM_054316961.1 → XP_054172936.1  serine/threonine-protein kinase WNK4 isoform X11

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