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    PDCL3 phosducin like 3 [ Homo sapiens (human) ]

    Gene ID: 79031, updated on 4-Jan-2025

    Summary

    Official Symbol
    PDCL3provided by HGNC
    Official Full Name
    phosducin like 3provided by HGNC
    Primary source
    HGNC:HGNC:28860
    See related
    Ensembl:ENSG00000115539 MIM:611678; AllianceGenome:HGNC:28860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A
    Summary
    This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 9.1), esophagus (RPKM 8.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PDCL3 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (100562993..100576739)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101021740..101035465)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101179455..101193201)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373506 Neighboring gene neuromedin S Neighboring gene ARPP19 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:101154295-101154846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101178200-101178996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11816 Neighboring gene uncharacterized LOC124906187 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC3062

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein folding chaperone  
    enables protein folding chaperone PubMed 
    enables protein folding chaperone PubMed 
    enables vascular endothelial growth factor receptor 2 binding  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization PubMed 
    involved_in angiogenesis  
    involved_in angiogenesis PubMed 
    involved_in apoptotic process  
    involved_in chaperone-mediated protein folding PubMed 
    involved_in negative regulation of chaperone-mediated protein folding PubMed 
    acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis PubMed 
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression PubMed 
    involved_in protein folding  
    involved_in protein stabilization PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinucleolar compartment PubMed 
    part_of protein-containing complex  

    General protein information

    Preferred Names
    phosducin-like protein 3
    Names
    IAP-associated factor VIAF1
    VIAF-1
    phPL3
    viral IAP-associated factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024065.5NP_076970.1  phosducin-like protein 3

      See identical proteins and their annotated locations for NP_076970.1

      Status: VALIDATED

      Source sequence(s)
      AI741007, BC001021
      Consensus CDS
      CCDS33261.1
      UniProtKB/Swiss-Prot
      B2RA00, Q53S68, Q9H2J4
      UniProtKB/TrEMBL
      B7Z6S0
      Related
      ENSP00000264254.6, ENST00000264254.11
      Conserved Domains (1) summary
      cd02988
      Location:8202
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      100562993..100576739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004890.2XP_016860379.1  phosducin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      B7Z6S0
      Conserved Domains (1) summary
      cd02988
      Location:15152
      Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      101021740..101035465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343842.1XP_054199817.1  phosducin-like protein 3 isoform X1

      UniProtKB/TrEMBL
      B7Z6S0
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