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    MCM2 minichromosome maintenance complex component 2 [ Homo sapiens (human) ]

    Gene ID: 4171, updated on 5-Jan-2025

    Summary

    Official Symbol
    MCM2provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 2provided by HGNC
    Primary source
    HGNC:HGNC:6944
    See related
    Ensembl:ENSG00000073111 MIM:116945; AllianceGenome:HGNC:6944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
    Expression
    Broad expression in bone marrow (RPKM 27.3), lymph node (RPKM 14.9) and 23 other tissues See more
    Orthologs
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    Genomic context

    See MCM2 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (127598411..127622436)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (130333077..130357098)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127317254..127341279)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127293720-127294299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127294300-127294878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127298480-127299441 Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene microRNA 6825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127307841-127308518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127308519-127309195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14690 Neighboring gene microRNA 7976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127316932-127317889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127335678-127336178 Neighboring gene uncharacterized LOC107986126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20458 Neighboring gene podocalyxin like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127357688-127358188 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:127386638-127386819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14696 Neighboring gene ankyrin repeat and BTB domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of minichromosome maintenance complex component 2 (MCM2) in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0030, MGC10606

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables DNA binding PubMed 
    enables DNA clamp loader activity  
    enables DNA replication origin binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA helicase activity  
    enables enzyme binding  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables histone binding PubMed 
    enables histone binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables single-stranded 3'-5' DNA helicase activity  
    enables single-stranded DNA binding  
    contributes_to single-stranded DNA helicase activity  
    Component Evidence Code Pubs
    part_of CMG complex PubMed 
    part_of CMG complex  
    part_of MCM complex  
    part_of MCM complex PubMed 
    part_of MCM complex PubMed 
    located_in chromatin PubMed 
    located_in chromosome, telomeric region PubMed 
    located_in cytoplasm PubMed 
    part_of nuclear origin of replication recognition complex  
    NOT located_in nucleolus PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM2
    Names
    cell devision cycle-like 1
    cyclin-like 1
    minichromosome maintenance deficient 2 (mitotin)
    minichromosome maintenance protein 2 homolog
    nuclear protein BM28
    NP_004517.2
    XP_024309299.1
    XP_054202535.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050771.1 RefSeqGene

      Range
      5055..29080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004526.4 → NP_004517.2  DNA replication licensing factor MCM2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      BC007938, DB100427
      Consensus CDS
      CCDS3043.1
      UniProtKB/Swiss-Prot
      P49736, Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7
      UniProtKB/TrEMBL
      B7Z8Z6
      Related
      ENSP00000265056.7, ENST00000265056.12
      Conserved Domains (3) summary
      smart00350
      Location:291 → 803
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:73 → 182
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:197 → 286
      MCM_N; MCM N-terminal domain

    RNA

    1. NR_073375.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK299934, BC000300

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      127598411..127622436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453531.2 → XP_024309299.1  DNA replication licensing factor MCM2 isoform X1

      UniProtKB/TrEMBL
      B7Z8Z6
      Conserved Domains (3) summary
      smart00350
      Location:282 → 794
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:64 → 173
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:190 → 278
      MCM_N; MCM N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      130333077..130357098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346560.1 → XP_054202535.1  DNA replication licensing factor MCM2 isoform X1

      UniProtKB/TrEMBL
      B7Z8Z6
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