Arhgef1 Rho guanine nucleotide exchange factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgef1provided by RGD
Official Full Name: Rho guanine nucleotide exchange factor 1provided by RGD
Primary source: RGD:620951
See related: EnsemblRapid:ENSRNOG00000020130 AllianceGenome:RGD:620951
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lsc; Lbcl2
Summary: Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in microtubule depolymerization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 296.9), Spleen (RPKM 246.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89626884..89648823)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80499026..80520954)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81769212..81797237)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactive oxygen species and SrcFK activate RhoA via ARHGEF1 in pulmonary artery.
Title: ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.
results indicate that ROCK and its downstream target molecules, which are involved in inducing the hypertrophic response, are also implicated in signaling the up-regulation of the p115RhoGEF protein.
Title: Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response.
These data establish a previously uncharacterized role for the exchange factors Lsc/p115 RhoGEF and LARG in linking fibronectin signals to downstream RhoA activation.
Title: A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

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General gene information

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Markers

AU047514 (e-PCR)
- UniSTS:110433

AU047512 (e-PCR)
- UniSTS:110435

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 1

Names: Lymphoid blast crisis-like 2; Rho guanine nucleotide exchange factor (GEF) 1; lbc's second cousin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021694.3 → NP_067726.3 rho guanine nucleotide exchange factor 1

Status: PROVISIONAL

Source sequence(s)

BC091218

UniProtKB/Swiss-Prot

Q9Z1I6

UniProtKB/TrEMBL

Q5BK37

Related

ENSRNOP00000072904.2, ENSRNOT00000080840.3

Conserved Domains (4) summary

pfam05887
Location:303 → 409

Trypan_PARP; Procyclic acidic repetitive protein (PARP)

cd08755
Location:50 → 242

RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF

smart00325
Location:418 → 602

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd14679
Location:636 → 760

PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

89626884..89648823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088933.2 → XP_038944861.1 rho guanine nucleotide exchange factor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JU01, E9PTJ8

Related

ENSRNOP00000068908.2, ENSRNOT00000080143.3

Conserved Domains (4) summary

cd08755
Location:50 → 242

RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF

smart00325
Location:474 → 658

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

PRK14086
Location:275 → 451

dnaA; chromosomal replication initiator protein DnaA

cd14679
Location:692 → 816

PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
XM_063272369.1 → XP_063128439.1 rho guanine nucleotide exchange factor 1 isoform X5
XM_063272371.1 → XP_063128441.1 rho guanine nucleotide exchange factor 1 isoform X6
XM_063272361.1 → XP_063128431.1 rho guanine nucleotide exchange factor 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JU01, E9PTJ8
XM_063272365.1 → XP_063128435.1 rho guanine nucleotide exchange factor 1 isoform X4

UniProtKB/Swiss-Prot

Q9Z1I6
XM_063272358.1 → XP_063128428.1 rho guanine nucleotide exchange factor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JU01, E9PTJ8
XM_063272364.1 → XP_063128434.1 rho guanine nucleotide exchange factor 1 isoform X3

UniProtKB/Swiss-Prot

Q9Z1I6

UniProtKB/TrEMBL

Q5BK37